Abstract
Abstract
Aim. To explore whether first-trimester levels of pregnancy-associated plasma protein-A (PAPP-A) and serum free ß-human chorionic gonadotrophin (free ß-hCG) vary with maternal blood group and rhesus status and to determine their implications for Down syndrome. Methods. Blood samples were collected from all 539 singleton pregnancies undergoing first-trimester screening. Values of maternal serum PAPP-A and ß-hCG were compared among women with different ABO and Rh groups. Results. Although ß-hCG MoM values were increased in Rh negative women compared with Rh positive controls, PAPP-A and ß-hCG MoM values did not differ significantly. Compared to other groups, the combined risk was higher in B Rh negative group (25%). Conclusions. A larger study is required to establish the validity of this correlation between groups. Corrections in the MoM values of serum analytes used in the first-trimester screening depending on the rhesus and ABO status of the pregnant women may be necessary.
Keywords: Prenatal screening,blood group,rhesus status
Özet
Amaç. İlk trimesterde pregnancy-associated plasma protein-A (PAPP-A) ve serum serbest ß-human chorionic gonadotropin (ß-HCG) düzeylerinin anne kan grubu ve rh durumuyla olan değişimlerinin incelenmesi ve bunların Down sendromuna etkilerinin araştırılması. Yöntem. Birinci trimester tarama yapılan 539 tekiz gebeliği olan kadından kan örnekleri toplandıktan sonra maternal serumdaki PAPP-A ve ß-HCG seviyeleri,değişik ABO ve Rh grupları arasında karşılaştırılmıştır. Bulgular. Her ne kadar ß-HCG MoM değerleri Rh negatif kadınlarda Rh pozitif kontrol grubuna göre artmışsa da PAPP-A ve ß-HCG MoM değerlerinde anlamlı bir değişim olmamıştır.B Rh negatif grupta diğer gruplara göre kombine risk yüksek bulunmuştur. Sonuçlar. Gruplar arası bu bağlantının değerinin kanıtlanması için geniş serili çalışmalara gerek vardır.İlk trimester tarama testlerindeki serum MoM değerlerinin gebe kadının ABO ve Rh durumuna göre düzeltilmesi gereklidir.
Anahtar sözcükler: Prenatal tarama, kan grupları, rh durumu
Keywords
References
- Spencer K, Heath V, El-Sheikhah A, Ong CY, Nicolaides KH. Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribian populations. Prenat Diagn 2005; 25:365-9.
- Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Multicenter study of first trimester screening for trisomy 21 in 75821 pregnancies:results and estimation of the potential impact of individual risk-oriented two-stage first-trimester screening. Ultrasound Obstet Gynecol 2005; 25: 221-6.
- Gajewska J, Ceran A, Chelchowska-Klita T. Effect of maternal smoking on concentrations of the pregnancy-associated plasma protein A(PAPP-A) and free beta subunit of chorionic gonadotropin (beta HCG) in the first trimester of pregnancy. Przegl Leh 2008; 65: 479-82.
- Mbugua Gitau G, Liversedge H, Goffey D, Hawton A, Liversedge N, Taylor M. The influence of maternal age on the outcomes of pregnancies complicated by bleeding at less than 12 weeks. Acta Obstet Gynecol Scand 2009; 88: 116-8.
- Werner EF, Pastore LM, Karns LB, Ventura K, Saller DN. Patient preferences for screening in the first trimester. Prenat Diagn 2008; 28: 1251-5.
- Sancken U, Bartels I .Preliminary data on an association between blood groups and serum markers used for the so-called ‘triple screening’: free oestriol MoM values are decreased in rhesus-negative (Rh-) women. Prenat Diagn 2001; 21: 194-5.
- Muhcu M, Mungen E, Dundar O. Reliability of second trimester triple screening for Down syndrome in rhesus-negative women. J Perinatol. 2007; 27: 268-71.
- Cowans NJ, Spencer K. Is there an association between maternal ABO and rhesus blood groups and the first trimester serum markers free beta-hCG and PAPP-A used for the detection of fetal aneuploidy? Prenat Diagn 2007; 27: 64-7.
- Scott F, Peters H, Bonifacio M, McLennan A, Boogert A, Kesby G, Anderson J. Prospective evaluation of a first trimester screening program for Down syndrome and other chromosomal abnormalities using maternal age, nuchal translucency and biochemistry in an Australian population. Aust N Z J Obstet Gynaecol 2004; 44: 205-9.
- Hughes G, Bischaf P, Klopper A. Relation between pregnancy-associated plasma protein A and fetal sex and blood group. Hum Hered 1983; 33: 69-72.
Abstract
Amaç. İlk trimesterde pregnancy-associated plasma protein-A (PAPP-A) ve serum serbest ßhuman chorionic gonadotropin (ß-HCG) düzeylerinin anne kan grubu ve rh durumuyla olan değişimlerinin incelenmesi ve bunların Down sendromuna etkilerinin araştırılması. Yöntem. Birinci trimester tarama yapılan 539 tekiz gebeliği olan kadından kan örnekleri toplandıktan sonra maternal serumdaki PAPP-A ve ß-HCG seviyeleri,değişik ABO ve Rh grupları arasında karşılaştırılmıştır. Bulgular. Her ne kadar ß-HCG MoM değerleri Rh negatif kadınlarda Rh pozitif kontrol grubuna göre artmışsa da PAPP-A ve ß-HCG MoM değerlerinde anlamlı bir değişim olmamıştır.B Rh negatif grupta diğer gruplara göre kombine risk yüksek bulunmuştur. Sonuçlar. Gruplar arası bu bağlantının değerinin kanıtlanması için geniş serili çalışmalara gerek vardır.İlk trimester tarama testlerindeki serum MoM değerlerinin gebe kadının ABO ve Rh durumuna göre düzeltilmesi gereklidir
Keywords
References
- Spencer K, Heath V, El-Sheikhah A, Ong CY, Nicolaides KH. Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribian populations. Prenat Diagn 2005; 25:365-9.
- Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Multicenter study of first trimester screening for trisomy 21 in 75821 pregnancies:results and estimation of the potential impact of individual risk-oriented two-stage first-trimester screening. Ultrasound Obstet Gynecol 2005; 25: 221-6.
- Gajewska J, Ceran A, Chelchowska-Klita T. Effect of maternal smoking on concentrations of the pregnancy-associated plasma protein A(PAPP-A) and free beta subunit of chorionic gonadotropin (beta HCG) in the first trimester of pregnancy. Przegl Leh 2008; 65: 479-82.
- Mbugua Gitau G, Liversedge H, Goffey D, Hawton A, Liversedge N, Taylor M. The influence of maternal age on the outcomes of pregnancies complicated by bleeding at less than 12 weeks. Acta Obstet Gynecol Scand 2009; 88: 116-8.
- Werner EF, Pastore LM, Karns LB, Ventura K, Saller DN. Patient preferences for screening in the first trimester. Prenat Diagn 2008; 28: 1251-5.
- Sancken U, Bartels I .Preliminary data on an association between blood groups and serum markers used for the so-called ‘triple screening’: free oestriol MoM values are decreased in rhesus-negative (Rh-) women. Prenat Diagn 2001; 21: 194-5.
- Muhcu M, Mungen E, Dundar O. Reliability of second trimester triple screening for Down syndrome in rhesus-negative women. J Perinatol. 2007; 27: 268-71.
- Cowans NJ, Spencer K. Is there an association between maternal ABO and rhesus blood groups and the first trimester serum markers free beta-hCG and PAPP-A used for the detection of fetal aneuploidy? Prenat Diagn 2007; 27: 64-7.
- Scott F, Peters H, Bonifacio M, McLennan A, Boogert A, Kesby G, Anderson J. Prospective evaluation of a first trimester screening program for Down syndrome and other chromosomal abnormalities using maternal age, nuchal translucency and biochemistry in an Australian population. Aust N Z J Obstet Gynaecol 2004; 44: 205-9.
- Hughes G, Bischaf P, Klopper A. Relation between pregnancy-associated plasma protein A and fetal sex and blood group. Hum Hered 1983; 33: 69-72.
Details
| Primary Language | English |
|---|---|
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | August 5, 2009 |
| Published in Issue | Year 2009Volume: 31 Issue: 4 |