Acute myeloblastic leukaemia in a patient with liver cirrhosis due to chronic hepatitis B during lamivudine therapy
Abstract
Abstract
There are several causes resulting in decompensation of compensated cirrhosis and disturbing ascites regulation. Besides, hematologic disorders including anemia, thrombocytopenia, leucopenia and coagulation disorders may also accompany cirrhosis. In this case, we discuss a patient with liver cirrhosis on lamivudine treatment with refractory ascites and pancytopenia, who developed acute myeloblastic leukemia during the course of the disease.
Keywords: Hepatitis B, liver cirrhosis, acute myeloblastic leukemia, lamivudine
Özet
Kompanze sirozun dekompanze olmasının ve asit regülasyonunun bozulmasının farklı nedenleri vardır. Ayrıca, anemi, trombositopeni, lökopeni ve pıhtılaşma bozuklukları gibi hematolojik bozukluklar da siroza eşlik edebilir. Bu vaka sunumunda, lamivudin kullanan karaciğer sirozlu bir hastada hastalığın seyri sırasında akut miyeloblastik lösemi gelişen refrakter asit ve pansitopenili bir vakayı tartıştık.
Anahtar sözcükler: Hepatit B, karaciğer sirozu, akut myeloblastik lösemi, lamivudine
Keywords
References
- Doti CA, Gondolesi GE, Sheiner PA, Emre S, Miller CM, Aledort LM. Leukemia after liver transplant. Transplantation 2001; 72: 1643-6.
- Yeung LT, Petric M, Cutz E, Roberts EA. Histological improvement with lamivudine therapy for de novo hepatitis B occuring in an anti-HBs-positive child after bone marrow transplantation. Bone Marrow Transplant 2002; 30: 459-62.
- Lin PC, Poh SB, Lee MY, Hsiao LT, Chen PM, Chiou TJ. Fatal fulminant hepatitis B after withdrawal of prophylactic lamivudine in hematopoietic stem cell transplantation patients. Int J Hematol 2005; 81: 349-51.
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- Fiel I, Strauchen JA, LoValvo R, Meyer RJ, Unger PD. Acute granulocytic leukemia with ascites as the initial manifestation. Acta Cytol 1995; 39: 608-9.
- Kojima H, Abei M, Takei N, Mukai Y, Hasegawa Y, lijima T, Nagasawa T. Fatal reactivation of hepatitis B virus following cytotoxic chemotherapy for acute myelogenous leukemia: fibrosing cholestatic hepatitis. Eur J Haematol 2002; 69: 101-4.
- Lee HK, Yoon GS, Min KS, Jung YW, Lee Ys, Suh DJ, Yu E. Fibrosing cholestatic hepatitis: a report of three cases. J Korean Med Sci 2000; 15: 111-4.
- Ikeda K, Shiga Y, Takahashi A, Kai T, Kimura H, Takeyama K, Noji H, Ogawa K, Nakamura A, Ohira H, Sato Y, Maruyama Y. Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment. Leuk Lymphoma 2006; 47: 155-7
- Orbuch SJ, Findor JA. Hodgkin's disease developing in the course of a chronic liver disease with ulcerative colitis immunosuppressed with azathioprine. Acta Gastroenterol Latinoam 1979; 9: 73-80.
- Chien RN, Yeh CT, Wang PN, Kuo MC, Hsieh SY, Shih LY, Liaw YF. Acute leukaemia in chronic hepatitis B patients with lamivudine therapy. Int J Clin Pract 2004; 58: 1088-91.
Acute Myeloblastic Leukaemia in a Patient With Liver Cirrhosis Duo To Chronic Hepatitis B With Lamivudine Therapy: A Case Report
Abstract
Abstract
There are several causes resulting in decompensation of compensated cirrhosis and disturbing acid regulation. Besides, hematologic disorders including anemia, thrombocytopenia, leucopenia and coagulation disorders may also accompany cirrhosis. In this case presentation, we discuss a patient with liver cirrhosis on lamivudine treatment with refractory ascites and pancytopenia, who developed acute myeloblastic leukemia during the course of the disease.
Key Words: Hepatitis B, liver cirrhosis, acute myeloblastic leukemia, lamivudine
References
- Doti CA, Gondolesi GE, Sheiner PA, Emre S, Miller CM, Aledort LM. Leukemia after liver transplant. Transplantation 2001; 72: 1643-6.
- Yeung LT, Petric M, Cutz E, Roberts EA. Histological improvement with lamivudine therapy for de novo hepatitis B occuring in an anti-HBs-positive child after bone marrow transplantation. Bone Marrow Transplant 2002; 30: 459-62.
- Lin PC, Poh SB, Lee MY, Hsiao LT, Chen PM, Chiou TJ. Fatal fulminant hepatitis B after withdrawal of prophylactic lamivudine in hematopoietic stem cell transplantation patients. Int J Hematol 2005; 81: 349-51.
- Geoffray A, Shirkhoda A, Wallace S. Abdominal and pelvic computed tomography in leukemic patients. J Comput Assist Tomogr 1984; 8: 857-60.
- Simel DL, Weinberg JB. Leukemic ascites complicating acute myelomonoblastic leukemia. Arch Pathol Lab Med 1985; 109: 365-7.
- Strittmatter C, Schneider J, Lüthy R, Schmid M. Stenosis of the terminal portal vein branch in acute myeloid leukemia. Schweiz Med Wochenschr 1991; 121: 1298-301.
- Fiel I, Strauchen JA, LoValvo R, Meyer RJ, Unger PD. Acute granulocytic leukemia with ascites as the initial manifestation. Acta Cytol 1995; 39: 608-9.
- Kojima H, Abei M, Takei N, Mukai Y, Hasegawa Y, lijima T, Nagasawa T. Fatal reactivation of hepatitis B virus following cytotoxic chemotherapy for acute myelogenous leukemia: fibrosing cholestatic hepatitis. Eur J Haematol 2002; 69: 101-4.
- Lee HK, Yoon GS, Min KS, Jung YW, Lee Ys, Suh DJ, Yu E. Fibrosing cholestatic hepatitis: a report of three cases. J Korean Med Sci 2000; 15: 111-4.
- Ikeda K, Shiga Y, Takahashi A, Kai T, Kimura H, Takeyama K, Noji H, Ogawa K, Nakamura A, Ohira H, Sato Y, Maruyama Y. Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment. Leuk Lymphoma 2006; 47: 155-7
- Orbuch SJ, Findor JA. Hodgkin's disease developing in the course of a chronic liver disease with ulcerative colitis immunosuppressed with azathioprine. Acta Gastroenterol Latinoam 1979; 9: 73-80.
- Chien RN, Yeh CT, Wang PN, Kuo MC, Hsieh SY, Shih LY, Liaw YF. Acute leukaemia in chronic hepatitis B patients with lamivudine therapy. Int J Clin Pract 2004; 58: 1088-91.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | March 14, 2011 |
| Published in Issue | Year 2011Volume: 33 Issue: 1 |