Abstract
References
- Practice Committee of American Society for Reproductive Medicine in collaboration consequences, and control of peritoneal adhesions in gynecologic surgery. Fertil Steril 2008; 90: S144-9. of Reproductive Surgeons. Pathogenesis,
- Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 2001; 18: 260-73.
- Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis Colon Rectum 2000; 43: 1297-9.
- Remah MK. Prevention of postoperative peritoneal adhesions. Eur J Obstet Gynecol Reprod Biol 2010: 150; 111-8.
- Nehéz L, Vödrös D, Axelsson J, Tingstedt B, Lindman B, Andersson R. Prevention of postoperative peritoneal adhesions: Effects of lysozyme, polylysine and polyglutamate versus hyaluronic acid. Scand J Gastroenterol 2005; 40: 1118- 23.
- Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2006: CD001298.
- Arıkan S, Adas G, Barut G, Toklu AS, Kocakuşak A, Uzun H, Kemik O, Daduk Y, Aydın S, Purisa S. An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing. Am J Surg 2005; 189: 155-2.
- Lai HS, Chen Y. Effect of octreotide on postoperative intraperitoneal adhesions in rats. Scand J Gastroenterol 1996: 31: 678-81.
- Lai HS, Chen Y, Chang KJ, Chen WJ. Effects of octreotide on epidermal growth factor receptor, tissue plasminogen activator, and plasminogen activator inhibitor during intraperitoneal adhesion formation. J Gastroenterol 2003; 38: 555-60.
- Türkçapar AG, Ozarslan C, Erdem E, Bumin C, Erverdi N, Kutlay J. The effectiveness of low molecular weight heparin on adhesion formation in experimental rat model. Int Surg 1995; 80: 92-4.
- Kumar S, Wong PF, Leaper DJ. Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynaecological abdominal surgery. Cochrane Database Syst Rev 2009; 21: CD005080.
- Kement M, Censur Z, Oncel M, Buyukokuroglu ME, Gezen FC. Heparin for adhesion prevention: Comparison of three different dosages with Seprafilm in a murine model. Int J Surg 2011; 9: 255-8.
- Şahin Y, Sağlam A. Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model. Acta Obstet Gynecol Scand 1994; 73: 70-3.
- Tayyar M, Turan R, Ayata D. The use of amniotic membrane plus heparin to prevent postoperative adhesions in the rabbit. Tokai J Exp Clin Med 1993; 18: 57-60.
- Tayyar M, Başbuğ M. The effects of intraperitoneal piroxicam and low molecular weight heparin in prevention of adhesion reformation in rat uterine horn. Res Exp Med 1999; 198: 269-75.
- Alatas E, Günal O, Alatas O, Colak O. Octreotide prevents postoperative adhesion formation by suppressing peritoneal myeloperoxidase activity. Hepatogastroenterology 2000; 47: 1034-6.
- Çolak T, Dağ A, Türkmenoğlu O, Polat A, Comelekoğlu U, Bağdatoğlu O, Polat G, Akca T, Sucullu I, Aydın S. The effect of octreotide on healing of injured colonic anastomosis with immediate postoperative intraperitoneal administration of 5-Fluorouracil. Dis Colon Rectum 2007; 50: 660-9.
- Sortini D, Feo CV, Maravegias K, Carcoforo P, Pozza E, Liboni A, Sortini A. Role of peritoneal lavage in adhesion formation and survival rate in rats: An experimental study. J Invest Surg 2006; 19: 291-7.
Sıçanlarda oluşturulan deneysel uterin horn adezyon modelinde düşük molekül ağırlıklı heparin ile oktreotidin etkileri
Abstract
Amaç. Düşük molekül ağırlıklı heparinin postoperatif adezyon önleyici etkinliği daha önce
yapılan çeşitli çalışmalarda öne sürülmüştür. Yine Growth hormon üzerinden etki ederek Insulin
like growth faktör inhibisyonuyla inflamatuar hücrelerin maturasyon ve migrasyonunu inhibe eden
oktreotidin adezyon önleyici etkisi yapılan bazı araştırmalarda gösterilmiştir.Bu çalışmada
adezyon gelişiminin farklı basamaklarına etki eden düşük moleküler ağırlıklı heparin ve
oktreotidin tek başlarına ve kombine kullanımları halinde adezyon oluşumunu önleyici etkilerinin
karşılaştırılması amaçlanmaktadır. Yöntem. Çalışmada ağırlığı 250-300 gr arasında değişen 40
adet Wistar-Albino tipi dişi sıçan kullanıldı. Sıçanlar randomize olarak 10’ar sıçanlık grup halinde
kontrol ve 3 adet çalışma gruplarına ayrıldı. Adezyon modeli oluşturulduktan sonra kontrol grubu
dışındaki diğer 3 gruba düşük moleküler ağırlıklı heparin, oktreotid ve düşük moleküler ağırlıklı
heparin ile oktreotid birlikte 14 gün süreyle uygulandı.14 gün sonra sıçanlar letal doz pentobarbital
ile öldürüldükten sonra orta hat insizyon ile laparotomi yapılarak adezyon gelişimi değerlendirildi.
Bulgular. Makroskopik olarak adezyon şiddeti 3 çalışma grubunda kontrol grubuna göre daha
düşük bulundu (p < 0,05). Kombine grupta adezyon şiddeti en az bulundu (p < 0,05). Adezyon
yaygınlığı 3 çalışma grubunda da kontrol grubundan az saptandı (p < 0,05). Ancak kombine grup
adezyon yaygınlık skoru oktreotid ve düşük moleküler ağırlıklı heparin gruplarından farksız
bulundu (p < 0,05). Mikroskopik adezyon skorlamasında ise oktreotid ve kombine grupta kontrol
grubuna göre belirgin olarak düşüklük izlendi (p < 0,05). Sonuç. Oktreotid ve düşük moleküler
ağırlıklı heparinin postoperatif intraabdominal adezyonları önlemede aynı derecede etkin olduğunu
gözlemledik. Kombine kullanımın ise izole düşük moleküler ağırlıklı heparin ve oktreotid
kullanımına göre adezyon şiddetini engellemedeki etkinliğinin daha fazla olduğu kanısına vardık
Keywords
References
- Practice Committee of American Society for Reproductive Medicine in collaboration consequences, and control of peritoneal adhesions in gynecologic surgery. Fertil Steril 2008; 90: S144-9. of Reproductive Surgeons. Pathogenesis,
- Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 2001; 18: 260-73.
- Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis Colon Rectum 2000; 43: 1297-9.
- Remah MK. Prevention of postoperative peritoneal adhesions. Eur J Obstet Gynecol Reprod Biol 2010: 150; 111-8.
- Nehéz L, Vödrös D, Axelsson J, Tingstedt B, Lindman B, Andersson R. Prevention of postoperative peritoneal adhesions: Effects of lysozyme, polylysine and polyglutamate versus hyaluronic acid. Scand J Gastroenterol 2005; 40: 1118- 23.
- Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2006: CD001298.
- Arıkan S, Adas G, Barut G, Toklu AS, Kocakuşak A, Uzun H, Kemik O, Daduk Y, Aydın S, Purisa S. An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing. Am J Surg 2005; 189: 155-2.
- Lai HS, Chen Y. Effect of octreotide on postoperative intraperitoneal adhesions in rats. Scand J Gastroenterol 1996: 31: 678-81.
- Lai HS, Chen Y, Chang KJ, Chen WJ. Effects of octreotide on epidermal growth factor receptor, tissue plasminogen activator, and plasminogen activator inhibitor during intraperitoneal adhesion formation. J Gastroenterol 2003; 38: 555-60.
- Türkçapar AG, Ozarslan C, Erdem E, Bumin C, Erverdi N, Kutlay J. The effectiveness of low molecular weight heparin on adhesion formation in experimental rat model. Int Surg 1995; 80: 92-4.
- Kumar S, Wong PF, Leaper DJ. Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynaecological abdominal surgery. Cochrane Database Syst Rev 2009; 21: CD005080.
- Kement M, Censur Z, Oncel M, Buyukokuroglu ME, Gezen FC. Heparin for adhesion prevention: Comparison of three different dosages with Seprafilm in a murine model. Int J Surg 2011; 9: 255-8.
- Şahin Y, Sağlam A. Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model. Acta Obstet Gynecol Scand 1994; 73: 70-3.
- Tayyar M, Turan R, Ayata D. The use of amniotic membrane plus heparin to prevent postoperative adhesions in the rabbit. Tokai J Exp Clin Med 1993; 18: 57-60.
- Tayyar M, Başbuğ M. The effects of intraperitoneal piroxicam and low molecular weight heparin in prevention of adhesion reformation in rat uterine horn. Res Exp Med 1999; 198: 269-75.
- Alatas E, Günal O, Alatas O, Colak O. Octreotide prevents postoperative adhesion formation by suppressing peritoneal myeloperoxidase activity. Hepatogastroenterology 2000; 47: 1034-6.
- Çolak T, Dağ A, Türkmenoğlu O, Polat A, Comelekoğlu U, Bağdatoğlu O, Polat G, Akca T, Sucullu I, Aydın S. The effect of octreotide on healing of injured colonic anastomosis with immediate postoperative intraperitoneal administration of 5-Fluorouracil. Dis Colon Rectum 2007; 50: 660-9.
- Sortini D, Feo CV, Maravegias K, Carcoforo P, Pozza E, Liboni A, Sortini A. Role of peritoneal lavage in adhesion formation and survival rate in rats: An experimental study. J Invest Surg 2006; 19: 291-7.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | January 16, 2012 |
| Published in Issue | Year 2012Volume: 34 Issue: 3 |