Verrucous squamous cell carcinoma arising in sacrococcygeal recurrent pilonidal sinus: A case report
Abstract
Abstract
Pilonidal sinus is an acquired and well described disease which is mostly located in sacrococcygeal midline region, lined by squamous epithelium and characterized by chronic inflammation including foreign body giant cells and sinus or sinuses containing epithelial debris and sometimes young granulation tissue. A malignant transformation can be seen in 0.1% of chronic or recurrent pilonidal sinus disease. The present case was 63 years old male patient undergoing pilonidal sinus operation 35 years ago. In the physical examination, there was an ulcerovegeteting mass of 10 cm in diameter, including multiple orifices of sinuses that contained purulent material drained by squeezing. The histopathological examination of the mass resected with wide excision revealed a typical verrucous squamous cell carcinoma. There were no lymphovascular and perineural invasions, also any distant metastases was observed in this case.
Keywords: Pilonidal sinus, squamous cell carcinoma, carcinomatous transformation
References
- Chintapatla S, Safarani N, Kumar S, Haboubi N. Sacrococcygeal pilonidal sinus: Historical review, pathological insight and surgical options. Tech Coloproctol 2003; 7: 3-8.
- Davage ON. The origin of sacrococsigeal pilonidal sinus: Based on an analysisof four hundred sixty-three cases. Am J Pathol 1954; 30: 1191-205.
- Ekmel T, ve ark. Pilonidal sinüs hastalığı ve tedavisine yeni bir bakış. Marmara Medical Journal 2009; 22; 85-9.
- Gur E, Neligan PC, Shafir R, Reznick R, Cohen M, Shpitzer T. Squamous cell carcinoma in perineal inflammatory disease. Ann Plast Surg 1997; 38: 653-7.
- Nigel Kirkham-Tumors and Cysts of the Epidermis, In: David E. Elder ed. Lever’s Histopathology of the Skin Ninth Edition, USA, Lippincott Williams & Wilkins 2005: 805-66.
- Cilingir M, Eroğlu S, Karacaoğlan N, Uysal A. Squamous carcinoma arising from chronic pilonidal disease. Plast Reconstr Surg 2002; 110: 1196-8. de Bree E, Zoetmulder FA, Christodoulakis M, Aleman BM, Tsiftsis DD. Treatment of malignancy arising in pilonidal disease. Ann Surg Oncol 2001; 8: 60Abboud B, Ingea H. Recurrent squamous-cell carcinoma arising in sacrococcygeal pilonidal sinus tract: Report of a case and review of the literature.Dis Colon Rectum 1999; 42: 525-8.
- Brenn T. Philip H McKee-Tumors of the Surface Epithelium In: Philip H McKee, Eduardo Calonje, Scott R Granter, eds. Pathology of the Skin with Clinical Correlations Vol 2 Third Edition, China, Elsevier Limited 2005: 1153-240.
VERRUCOUS SQUAMOUS CELL CARCINOMA ARISING IN SACROCOCCYGEAL RECURRENT PİLONİDAL SİNUS: A CASE REPORT
Abstract
ABSTRACT:Pilonidal sinus is an acquired and well described disease which is mostly located in secrococygeal midline region, lined by squamous epithelium and characterized by chronic inflammation including foreign body giant cells and sinus or sinuses containing epithelial debris and sometimes young granulation tissue. A malignant transformation can be seen in 0,1% of chronic or recurrent pilonidal sinus disease. The present case was 63 years old male patient undergoing pilonidal sinus operation 35 years ago. In the physical examination, there was an ulcerovegeteting mass of 10 cm in diameter, including multiple orifices of sinuses that contained purulent material drained by squeezing. The histopathological examination of the mass resected with wide excision revealed a typical verrucous squamous cell carcinoma.There were no lymphovascular and perineural invasions, also any distant metastases was observed in this case. The pathophysiology of carcinomatous transformation in pilonidal sinus disease having a high rate of local recurrence is suggested due to disruption of DNA repairment by chronic inflammation and free oxygen radicals that released by inflammatory cells. In these cases which can be easily diagnosed on clinical fincings, the condition of remaining untreated for long time may cause intractable malignancies.
References
- Chintapatla S, Safarani N, Kumar S, Haboubi N. Sacrococcygeal pilonidal sinus: Historical review, pathological insight and surgical options. Tech Coloproctol 2003; 7: 3-8.
- Davage ON. The origin of sacrococsigeal pilonidal sinus: Based on an analysisof four hundred sixty-three cases. Am J Pathol 1954; 30: 1191-205.
- Ekmel T, ve ark. Pilonidal sinüs hastalığı ve tedavisine yeni bir bakış. Marmara Medical Journal 2009; 22; 85-9.
- Gur E, Neligan PC, Shafir R, Reznick R, Cohen M, Shpitzer T. Squamous cell carcinoma in perineal inflammatory disease. Ann Plast Surg 1997; 38: 653-7.
- Nigel Kirkham-Tumors and Cysts of the Epidermis, In: David E. Elder ed. Lever’s Histopathology of the Skin Ninth Edition, USA, Lippincott Williams & Wilkins 2005: 805-66.
- Cilingir M, Eroğlu S, Karacaoğlan N, Uysal A. Squamous carcinoma arising from chronic pilonidal disease. Plast Reconstr Surg 2002; 110: 1196-8. de Bree E, Zoetmulder FA, Christodoulakis M, Aleman BM, Tsiftsis DD. Treatment of malignancy arising in pilonidal disease. Ann Surg Oncol 2001; 8: 60Abboud B, Ingea H. Recurrent squamous-cell carcinoma arising in sacrococcygeal pilonidal sinus tract: Report of a case and review of the literature.Dis Colon Rectum 1999; 42: 525-8.
- Brenn T. Philip H McKee-Tumors of the Surface Epithelium In: Philip H McKee, Eduardo Calonje, Scott R Granter, eds. Pathology of the Skin with Clinical Correlations Vol 2 Third Edition, China, Elsevier Limited 2005: 1153-240.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | February 14, 2014 |
| Published in Issue | Year 2013Volume 35, Issue 4 (2013): Supplement |