Abstract
Abstract
Metastasis to female genital tract are most commonly seen in the ovaries and it is very rare for uterus to have metastasis from extragenital organs. Metastatic carcinoma in an endometrial polyp is exceptional and presented as case reports in the literature. The presented case was a 52 year old woman, having metastatic breast carcinoma of invasive ductal type. She admitted to the gynecology department, with the complaint of postmenapausal bleeding. The pathological examination revealed a hyperplastic endometrial polyp, having a focus of epiteloid cellular infiltration in the stroma. The immunohistochemical staining showed these cells to be CD 10 negative, Pancytkeratin and GCDFP-15 positive. Pathological diagnosis was hyperplastic polyp, with focal carcinoma infiltration (compatible with breast carcinoma). The curettage specimens of the patients being followed for breast carcinoma is frequently seen in the daily routine of the pathology. The probability of metastatic disease must be kept in mind and the whole curretage materials must be evaluated. The pathological examination must be carefully made for the exclusion of a metastatic carcinoma.
Keywords: Endometrium, metastasis, breast carcinoma, endometrial polyp
Özet
Kadın genital sistemde metastazlar en sık overlerde görülür ve uterus için ekstragenital organlar dışında metastaz alımı çok nadirdir. Endometrial polipe metastaz ististani bir durum olup, literatürde olgu sunumları şeklinde yer almaktadır. Sunulan olgu 52 yaşında, metastatik invaziv duktal tip meme karsinomu olan kadın hastadır. Hasta jinekoloji bölümüne postmenapozal kanama şikayeti ile başvurdu. Patolojik incelemede hiperplastik tipte endometrial polip ve fokal bir alanda stroma içinde epiteloid hücre infiltrasyonu izlendi. İmmunohistokimyasal incelemede bu hücrelerin CD10 negatif, Pansitokeratin ve GCDFP-15 ile pozitif olduğu görüldü. Patolojik tanı fokal karsinom infiltrasyonu (meme kanseri ile uyumlu) içeren hiperplastik polip olarak raporlandı. Meme karsinomu tanısı ile takip edilen hastalara ait küretaj materyalleri patoloji rutininde sıkça görülmektedir. Metastatik hastalık olasılığı akılda tutulmalı, materyalin tamamı incelemeye alınmalı ve patolojik inceleme; metastatik hastalığı ekarte etmek üzere dikkatle yapılmalıdır.
Anahtar sözcükler: Karsinoma, duktal, meme, tümör metastazı, endometriyal tümörlerReferences
- Kurman RJ, Zaino RJ, Norris HJ. Endometrial carcinomas, in Kurman RJ (ed.): Blaustein’s Pathology of the Female Genital Tract. Spring-Verlag, New York, 20 Lambot MA, Eddafali B, Simon P, Fayt I, Noe JC. Metastasis from apocrine carcinoma of the breast to an endometrial polyp. Virchows Arch 2001; 438: 517
- Aranda FI, Laforga JB, Martinez MA. Metastasis from breast lobular carcinoma to an endometrial polyp. Report of a case with immunohistochemical study. Acta Obstet Gynecol Scand 1993; 72: 585-7.
- Horn LC, Einenkel J, Baier D. Endometrial metastasis from breast cancer in a patient receiving tamoxifen therapy. Gynecol Obstet Invest 2000; 50: 136-8. Alvarez C, Ortiz-Rey JA, Estévez F, de la Fuente A. Metastatic lobular breast carcinoma to an endometrial polyp diagnosed by hysteroscopic biopsy. Obstet Gynecol 2003; 102: 1149-51.
- Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG. Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions. Mod Pathol 2003; 16: 395-8.
- Al-Brahim N, Elavathil LJ. Metastatic breast lobular carcinoma to tamoxifenassociated endometrial polyp: case report and literature review. Ann Diagn Pathol 2005; 9: 166-8.
- Manipadam MT, Walter NM, Selvamani B. Lobular carcinoma metastasis to endometrial polyp unrelated to tamoxifen. Report of a case and review of the literature. APMIS 2008; 116: 538-40.
- Hooker AB, Radder CM, van de Wiel B, Geenen MM. Metastasis from breast cancer to an endometrial polyp; treatment options and follow-up. Report of a case and review of the literature. Eur J Gynaecol Oncol 2011; 32: 228-30.
- Aydın O, Bağcı P, Akyıldız EU, Özgüroğlu M, İlvan S. Metastasis from breast carcinoma to endometrial polyp. Eur J Gynaecol Oncol 2008; 29: 666-8.
- Meydanlı MM, Karadağ N, Ataoğlu O, Kafkaslı A. Uterine metastasis from infiltrating ductal carcinoma of breast in a patient receiving tamoxifen. Breast 2002; 11: 353-6.
- Açıkalın MF, Öner U, Tekin B, Yavuz E, Cengiz O. Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp. Gynecol Oncol 2005; 97: 946Sullivan LG, Sullivan JL, Fairey WF. Breast carcinoma metastatic to endometrial polyp. Gynecol Oncol 1990; 39: 96-8.
- Karvouni E, Papakonstantinou K, Dimopoulou C, Kairi-Vassilatou E, Hasiakos D, Gennatas CG, Kondi-Paphiti A. Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. Arch Gynecol Obstet 2009; 279: 199-201.
- Ustaalioğlu BB, Bilici A, Şeker M, Salman T, Gümüş M, Barışık NO, Salepci T, Yaylacı M. Metastasis of lobular breast carcinoma to the uterus in a patient under anastrozole therapy. Onkologie 2009; 32: 424-6.
- Sinkre P, Milchgrub S, Miller DS, Albores-Saavedra J, Hameed A. Uterine metastasis from a heterologous metaplastic breast carcinoma simulating a primary uterine malignancy. Gynecol Oncol 2000; 77: 216-8.
Abstract
Kadın genital sistemde metastazlar en sık overlerde görülür ve uterus için ekstragenital organlar dışından metastaz alımı çok nadirdir. Endometrial polipe metastaz ististani bir durum olup, literatürde olgu sunumları şeklinde yer almaktadır. Sunulan olgu 52 yaşında, metastatik invaziv duktal tip meme karsinomu olan kadın hastadır. Hasta jinekoloji bölümüne postmenapozal kanama şikayeti ile başvurdu. Patolojik incelemede hiperplastik tipte endometrial polip ve fokal bir alanda stroma içinde epiteloid hücre infiltrasyonu izlendi. İmmunohistokimyasal incelemede bu hücrelerin CD10 negatif, Pansitokeratin ve GCDFP-15 ile pozitif olduğu görüldü. Patolojik tanı fokal karsinom infiltrasyonu (meme kanseri ile uyumlu) içeren hiperplastik polip olarak raporlandı. Meme karsinomu tanısı ile takip edilen hastalara ait küretaj materyalleri patoloji rutininde sıkça yer almaktadır. Metastatik hastalık olasılığı akılda tutulmalı, materyalin tamamı incelemeye alınmalı ve patolojik inceleme; metastatik hastalığı ekarte etmek üzere dikkatle yapılmalıdır.
References
- Kurman RJ, Zaino RJ, Norris HJ. Endometrial carcinomas, in Kurman RJ (ed.): Blaustein’s Pathology of the Female Genital Tract. Spring-Verlag, New York, 20 Lambot MA, Eddafali B, Simon P, Fayt I, Noe JC. Metastasis from apocrine carcinoma of the breast to an endometrial polyp. Virchows Arch 2001; 438: 517
- Aranda FI, Laforga JB, Martinez MA. Metastasis from breast lobular carcinoma to an endometrial polyp. Report of a case with immunohistochemical study. Acta Obstet Gynecol Scand 1993; 72: 585-7.
- Horn LC, Einenkel J, Baier D. Endometrial metastasis from breast cancer in a patient receiving tamoxifen therapy. Gynecol Obstet Invest 2000; 50: 136-8. Alvarez C, Ortiz-Rey JA, Estévez F, de la Fuente A. Metastatic lobular breast carcinoma to an endometrial polyp diagnosed by hysteroscopic biopsy. Obstet Gynecol 2003; 102: 1149-51.
- Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG. Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions. Mod Pathol 2003; 16: 395-8.
- Al-Brahim N, Elavathil LJ. Metastatic breast lobular carcinoma to tamoxifenassociated endometrial polyp: case report and literature review. Ann Diagn Pathol 2005; 9: 166-8.
- Manipadam MT, Walter NM, Selvamani B. Lobular carcinoma metastasis to endometrial polyp unrelated to tamoxifen. Report of a case and review of the literature. APMIS 2008; 116: 538-40.
- Hooker AB, Radder CM, van de Wiel B, Geenen MM. Metastasis from breast cancer to an endometrial polyp; treatment options and follow-up. Report of a case and review of the literature. Eur J Gynaecol Oncol 2011; 32: 228-30.
- Aydın O, Bağcı P, Akyıldız EU, Özgüroğlu M, İlvan S. Metastasis from breast carcinoma to endometrial polyp. Eur J Gynaecol Oncol 2008; 29: 666-8.
- Meydanlı MM, Karadağ N, Ataoğlu O, Kafkaslı A. Uterine metastasis from infiltrating ductal carcinoma of breast in a patient receiving tamoxifen. Breast 2002; 11: 353-6.
- Açıkalın MF, Öner U, Tekin B, Yavuz E, Cengiz O. Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp. Gynecol Oncol 2005; 97: 946Sullivan LG, Sullivan JL, Fairey WF. Breast carcinoma metastatic to endometrial polyp. Gynecol Oncol 1990; 39: 96-8.
- Karvouni E, Papakonstantinou K, Dimopoulou C, Kairi-Vassilatou E, Hasiakos D, Gennatas CG, Kondi-Paphiti A. Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. Arch Gynecol Obstet 2009; 279: 199-201.
- Ustaalioğlu BB, Bilici A, Şeker M, Salman T, Gümüş M, Barışık NO, Salepci T, Yaylacı M. Metastasis of lobular breast carcinoma to the uterus in a patient under anastrozole therapy. Onkologie 2009; 32: 424-6.
- Sinkre P, Milchgrub S, Miller DS, Albores-Saavedra J, Hameed A. Uterine metastasis from a heterologous metaplastic breast carcinoma simulating a primary uterine malignancy. Gynecol Oncol 2000; 77: 216-8.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | December 30, 2013 |
| Published in Issue | Year 2013Volume: 35 Issue: 4 |