Abstract
Eosinophilic granuloma is a rare bone tumor, representing less than 1% of all bone tumors. Eosinophilic granuloma is the benign form of three clinical variants of Langerhans cell histiocytosis (LCH). It commonly affects children and young adults, particularly males. The characteristic cytologic features of eosinophilic granuloma include langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils and lymphocytes. We are reporting a case of eosinophilic granuloma of skull in a 7 years child diagnosed on fine needle aspiration cytology (FNAC). We here by emphasize the importance of rapid and reliable diagnosis of LCH by FNAC and the need to consider the possibility of LCH in the differential diagnosis of a slide showing a large number of histiocytes and eosinophils.
References
- Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E. Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Upsala J Med Sci 2008: 113: 209-16.
- Jain A, Alam K, Maheshwari V, Jain V, Khan R. Solitary eosinophilic granuloma of the ulna: Diagnosis on fine needle aspiration cytology. Journal of Cytol 2008; 25: 153-6.
- Jon A, Vinay K. White cells, lymph nodes, spleen and thymus. In Ramzi Sc, Vinay K, Tucker C, eds. Robbins pathologic Basis of Disease. 6th ed. W.B. Saunders Co. 1999:685.
- Kaul R, Gupta N, Gupta S, Gupta M. Eosinophilic granuloma of skull bone. J Cytol 2009; 26: 156-7.
- Kitsoulis PV, Paraskevas G, Vrettakos A, Marini A. A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases Journal 2009; 2: 91
- Weiss LM, Grogan TM, Muller-hermelink, Stein H, Dura T, Favara B, Paulli M, Feller AC. Langerhans cell histiocytosis. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Pathology and genetics of tumors of haematopoietic and lymphoid tissue. Lyon: IARC Press; 2001; p: 280-2.
- Chacha PB, Khong BT. Eosinophilic granuloma of bone. A diagnostic problem. Clin Orthop 1971; 80: 79-88.
- Mukhopadhyay S, Mitra PK, Ghosh S. Touton like giant cell in lymph node in a case of langerhans cell histiocytosis. Journal of Cytol 2007; 24: 191-2. Kumar PV, Mousavi A, Karimi M, Bedayat GR. Fine needle aspiration of Langerhans cell histiocytosis of the lymph nodes. A report of six cases. Acta Cytol 2002; 46: 753-6.
- Shetty S, Kumar A, Irshenavar SS. Eosinophilic granuloma of ileum: a case report. J Orthopaedics 2007; 4: 25.
- Rawlings CE 3rd, Wilkins RH. Solitary eosinophilic granuloma of the skull. Neurosurgery 1984; 15: 155-61.
- Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA. Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br 2002; 84: 870-2.
Abstract
Eozinofilik granülom nadir bir kemik tümörü olup, tüm kemik tümörlerinin %1’inden azını oluşturmaktadır. Eozinofilik granülom, üç klinik varyantı olan Langerhans hücreli histiositozisin (LHH) benign formudur. Çoğunlukla çocukları ve genç erişkinleri özellikle de erkekleri etkiler. Eozinofilik granülomun karakteristik sitolojik yapısı histiyositler, eozinofiller, nötrofiller ve lenfositleri içeren tipik bir ortamda langerhans hücrelerinin bulunmasıdır. Bu makalede ince iğne aspirasyon biyopsisi (İİAB) ile tanı alan yedi yaşında bir eozinofilik granülom olgusu sunulmaktadır. Burada özellikle İİAB ile LHH’e hızlı ve güvenilir bir şekilde tanı koyulabileceğini ve üzerinde çok sayıda histiyosit ve eozinofil bulunan bir ince iğne aspirasyon yaymasında ayırıcı tanıda LHH olasılığının bulunması gerektiğini vurgulamak istiyoruz.
References
- Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E. Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Upsala J Med Sci 2008: 113: 209-16.
- Jain A, Alam K, Maheshwari V, Jain V, Khan R. Solitary eosinophilic granuloma of the ulna: Diagnosis on fine needle aspiration cytology. Journal of Cytol 2008; 25: 153-6.
- Jon A, Vinay K. White cells, lymph nodes, spleen and thymus. In Ramzi Sc, Vinay K, Tucker C, eds. Robbins pathologic Basis of Disease. 6th ed. W.B. Saunders Co. 1999:685.
- Kaul R, Gupta N, Gupta S, Gupta M. Eosinophilic granuloma of skull bone. J Cytol 2009; 26: 156-7.
- Kitsoulis PV, Paraskevas G, Vrettakos A, Marini A. A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases Journal 2009; 2: 91
- Weiss LM, Grogan TM, Muller-hermelink, Stein H, Dura T, Favara B, Paulli M, Feller AC. Langerhans cell histiocytosis. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Pathology and genetics of tumors of haematopoietic and lymphoid tissue. Lyon: IARC Press; 2001; p: 280-2.
- Chacha PB, Khong BT. Eosinophilic granuloma of bone. A diagnostic problem. Clin Orthop 1971; 80: 79-88.
- Mukhopadhyay S, Mitra PK, Ghosh S. Touton like giant cell in lymph node in a case of langerhans cell histiocytosis. Journal of Cytol 2007; 24: 191-2. Kumar PV, Mousavi A, Karimi M, Bedayat GR. Fine needle aspiration of Langerhans cell histiocytosis of the lymph nodes. A report of six cases. Acta Cytol 2002; 46: 753-6.
- Shetty S, Kumar A, Irshenavar SS. Eosinophilic granuloma of ileum: a case report. J Orthopaedics 2007; 4: 25.
- Rawlings CE 3rd, Wilkins RH. Solitary eosinophilic granuloma of the skull. Neurosurgery 1984; 15: 155-61.
- Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA. Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br 2002; 84: 870-2.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | May 5, 2013 |
| Published in Issue | Year 2013Volume: 35 Issue: 4 |