Abstract
SUMMARY
Infestation with head lice is a worldwide public health concern. In high income countries pediculosis capitis is a problem mainly in school-aged children. In the last two decades and mainly as a result of resistance to pediculicides with a neurotoxic mode of action and due to the toxicological concerns, a new trend to products acting by physical means such as dimethicone, has been observed. It was shown that these substances are capable of entering the tracheal system and asphyxiating the lice and their eggs. Due to this quality it could be expected that lice, if at all, could not easily develop resistance. Dimethicone is a cosmetically acceptable product, physiologically inert and non-toxic and therefore it is expected to become the treatment-of-choice for lice in the near future.
Keywords: Head louse, Pediculus humanus capitis, control, dimethicone, louse comb
ÖZET
Saç biti enfestasyonu tüm dünyada yaygın bir halk sağlığı sorunudur. Yüksek gelirli ülkelerde pedikülozis kapitis temel olarak okul çağındaki çocuklarda problemdir. Son 20 yılda özellikle nörotoksik yolla etkili pedikülositlere direnç gelişimi ve toksikolojik endişeler nedeniyle, dimetikon gibi fiziksel olarak etkili yeni ürünlere eğilim görülmeye başlanmıştır. Bu maddelerin trakeal sisteme girerek bitleri ve yumurtalarını boğduğu gösterilmiştir. Bu niteliğine bağlı olarak bitlerin en azından kolaylıkla direnç geliştiremeyeceği beklenmektedir. Dimetikon kozmetik açıdan kabul edilebilir, fizyolojik olarak etkisiz ve toksik olmayan bir üründür. Bu nedenle yakın gelecekte bitlerin tedavisinde seçenek olması beklenmektedir.
Anahtar sözcükler: Saç biti, Pedikülus humanus kapitis, kontrol, dimetikon, bit tarağı
References
- 1. Mumcuoglu KY, Barker SC, Burgess IF. International guidelines for effective control of head louse infestations. J. Drugs Dermatol 2007; 6: 409-14.
- 2. Mumcuoglu KY. Control of head louse (Anoplura: Pediculidae) infestations: Past and present. Amer. Entomol 1996; 42: 175-8.
- 3. Mumcuoglu KY. Effective treatment of head louse with pediculicides. J. Drugs Dermatol 2006; 5: 451-2.
- 4. Hemingway J, Miller J, Mumcuoglu KY. Pyrethroid resistance mechanisms in the head louse Pediculus humanus capitis from Israel: Implications for control. Med. Vet. Entomol 1999; 13: 89-96.
- 5. Burgess IF. The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis. BMC Pharmacology 2009; 9: 3.
- 6. Burgess IF, Brown CM, Lee PN. Treatment of head louse infestation with 4% dimeticone lotion: Randomised controlled equivalence trial. BMJ 2005; 330; 1423.
- 7. Burgess IF, Lee PN, Matlock G. Randomised, controlled, assessor blind trial comparing 4% dimeticone lotion with 0.5% malathion liquid for head louse infestation. PLoS 2007; 2: 1127.
- 8. Burgess IF, Brunton ER, Burgess NA. Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin crème rinse for treatment of head louse infestation: A randomised controlled trial. BMC Dermatology 2013; 13: 5.
- 9. Heukelbach J, Pilger D, Oliveira FA, Khakban A. Ariza L, Feldmeier H. Efficacious pediculicide based on dimeticone: Randomized observer blinded comparative trial. BMC Infectious Diseases 2008; 8: 115.
- 10. Heukelbach J. Asenov A, Liesenfeld O, Mirmohammadsadegh A, Oliveira FA. A new two phase dimeticone pediculicide shows high efficacy in a comparative bioassay. BMC Dermatology 2009; 9: 12.
- 11. Richling I, Böckeler W. Lethal effects of treatment with a special dimeticone formula on head lice and house crickets Insights into physical mechanisms. Arzneimittelforschung 2008; 58: 248-254.
- 12. Kurt O, Balcioğlu IC, Burgess IF, Limoncu ME, Girginkardeşler N, Tabak T, Muslu H, Ermiş O, Sahin MT, Bilac C, Kavur H, Ozbel Y. Treatment of head lice with dimeticone 4% lotion: Comparison of two formulations in a randomised controlled trial in rural Turkey. BMC Public Health 2009; 9: 441.
Abstract
Saç biti enfestasyonu tüm dünyada yaygın bir halk sağlığı sorunudur. Yüksek gelirli ülkelerde pedikülozis kapitis temel olarak okul çağındaki çocuklarda problemdir. Son 20 yılda özellikle nörotoksik yolla etkili pedikülositlere direnç gelişimi ve toksikolojik endişeler nedeniyle, dimetikon gibi fiziksel olarak etkili yeni ürünlere eğilim görülmeye başlanmıştır. Bu maddelerin trakeal sisteme girerek bitleri ve yumurtalarını boğduğu gösterilmiştir. Bu niteliğine bağlı olarak bitlerin en azından kolaylıkla direnç geliştiremeyeceği beklenmektedir. Dimetikon kozmetik açıdan kabul edilebilir, fizyolojik olarak etkisiz ve toksik olmayan bir üründür. Bu nedenle yakın gelecekte bitlerin tedavisinde seçenek olması beklenmektedir
References
- 1. Mumcuoglu KY, Barker SC, Burgess IF. International guidelines for effective control of head louse infestations. J. Drugs Dermatol 2007; 6: 409-14.
- 2. Mumcuoglu KY. Control of head louse (Anoplura: Pediculidae) infestations: Past and present. Amer. Entomol 1996; 42: 175-8.
- 3. Mumcuoglu KY. Effective treatment of head louse with pediculicides. J. Drugs Dermatol 2006; 5: 451-2.
- 4. Hemingway J, Miller J, Mumcuoglu KY. Pyrethroid resistance mechanisms in the head louse Pediculus humanus capitis from Israel: Implications for control. Med. Vet. Entomol 1999; 13: 89-96.
- 5. Burgess IF. The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis. BMC Pharmacology 2009; 9: 3.
- 6. Burgess IF, Brown CM, Lee PN. Treatment of head louse infestation with 4% dimeticone lotion: Randomised controlled equivalence trial. BMJ 2005; 330; 1423.
- 7. Burgess IF, Lee PN, Matlock G. Randomised, controlled, assessor blind trial comparing 4% dimeticone lotion with 0.5% malathion liquid for head louse infestation. PLoS 2007; 2: 1127.
- 8. Burgess IF, Brunton ER, Burgess NA. Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin crème rinse for treatment of head louse infestation: A randomised controlled trial. BMC Dermatology 2013; 13: 5.
- 9. Heukelbach J, Pilger D, Oliveira FA, Khakban A. Ariza L, Feldmeier H. Efficacious pediculicide based on dimeticone: Randomized observer blinded comparative trial. BMC Infectious Diseases 2008; 8: 115.
- 10. Heukelbach J. Asenov A, Liesenfeld O, Mirmohammadsadegh A, Oliveira FA. A new two phase dimeticone pediculicide shows high efficacy in a comparative bioassay. BMC Dermatology 2009; 9: 12.
- 11. Richling I, Böckeler W. Lethal effects of treatment with a special dimeticone formula on head lice and house crickets Insights into physical mechanisms. Arzneimittelforschung 2008; 58: 248-254.
- 12. Kurt O, Balcioğlu IC, Burgess IF, Limoncu ME, Girginkardeşler N, Tabak T, Muslu H, Ermiş O, Sahin MT, Bilac C, Kavur H, Ozbel Y. Treatment of head lice with dimeticone 4% lotion: Comparison of two formulations in a randomised controlled trial in rural Turkey. BMC Public Health 2009; 9: 441.
Details
| Primary Language | English |
|---|---|
| Journal Section | Reviews |
| Authors | |
| Publication Date | March 27, 2015 |
| Published in Issue | Year 2015Volume: 37 Issue: 1 |