Research Article
Year 2019,
Volume: 41 Issue: 2, 379 - 384, 30.06.2019
Abstract
References
- 1. Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005; 365: 785–7992. Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179: 1359–1375.3. Chaiworapongsa T, Romero R, Kim YM, Kim GJ, Kim MR, Espinoza J, et al. Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of preeclampsia.J Matern Fetal Neonatal Med 2005;17:3–18.4. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006;355:992–10055. Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 2008;21:9–23.6. Solomon CG, Seely EW. Brief review: hypertension in pregnancy : a manifestation of the insulin resistance syndrome? Hypertension 2001;37:232–239.7.Roberts JM,GammillHS. Preeclampsia: recent insights.Hypertension 2005;46:1243–9.8. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science2005;308:1592–1594.9. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. 2002. Obstet Gynecol 2002; 99:159–167.10. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356–362.11. Zavalza-Gomez AB, et al. Adipokines and insulin resistance during pregnancy.Diabetes Res Clin Pract 2008;80:8–15.12. Vaisbuch E, Romero R, Mazaki-Tovi S, Erez O, Kim KS, Chaiworapongsa T et al. Retinol binding protein 4 - a novel association with early-onset preeclampsia. J Perinat Med 2010, 38(2): 129–139.13. Miehle K, Stepan H and Mathias Fasshauer. Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia. Clinical Endocrinology 2012; 76: 2–11.14.Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006;354:2552–2563.15. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH et al. Plasma Retinol Binding Protein-4 concentrations are elavated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 2006; 29: 2457–2461.16. Chan TF, Chen HS, Chen YC, Lee CH, Chou FH, Chen IJ, et al. Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus. Reprod Sci 2007;14:169–174.17. Klein K, Todesca DB, Leipold H, Knöfler M, Haslinger P, Handisurya A. Retinol Binding Protein 4 in Patients with Gestational Diabetes Mellitus. J of Women’s Health 2010; 19: 517-521.18. Stepan, H., Ebert, T., Schrey, S. et al. Preliminary report: serum levels of retinol-binding protein 4 in preeclampsia. Metabolism 2009; 58: 275–277. [19. Kholy AA, Abadier MZ, Rageh EM, Kallaf HE. Seeum levels of placental growth factor and retinol binding protein-4 in pregnancy induced hypertensive women. J Am Science 2010; 6: 448–455.20. Masuyama, H., Inoue, S. & Hiramatsu, Y. Retinol-binding protein 4 and insulin resistance in preeclampsia. Endocrine Journal, 2011; 58: 47–53.21. Shangguan, X, Liu F, Wang H, He J, Dong M. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clinica Chimica Acta 2009; 407: 58–61.22. Inoue S, Takamoto, N., Akahori, Y, Akahori Y, Masumoto A, Nakatsukasa H. Elevated level of serum retinol-binding protein 4 in pregnancy-induced hypertension.. The Journal of Obstetrics and Gynaecology Research 2009; 35: 293–300.23. Catalano PM, et al. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 1999;180:903–16.24. Barbour LA, et al. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol 2002;186:512–7.25. Nanda, S, Yu, C.K, Giurcaneanu. Maternal serum adiponectin at 11–13 weeks of gestation in preeclampsia. Fetal Diagnosis and Therapy 2011; 29: 208–215.26. Mazaki-Tovi, S., Vaisbuch, E., Romero, R. Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate. The Journal of Maternal-Fetal & Neonatal Medicine 2010; 23: 1119–1128.27. Moore, L.E., Wallace, K.L., Alexander, B.T. Reduced placental perfusion causes an increase in maternal serum leptin. Placenta 2003; 24: 877–881.28. Haffner S. Epidemioliogy of hypertension and insulin resistance syndrome. J hypertens 1997; 15: 25–30. 29. Ferrannini E, Buzzigoli G, Bonadonna R et al. Insulin resistance in essential hypertension. Diabetes Care 2004; 27: 274-275.30. Seol, H.J., Kim, J.W. & Kim, H.J. Retinol-binding protein- 4 is decreased in patients with preeclampsia in comparison with normal pregnant women. Journal of Perinatal Medicine 2011; 39: 287–289.
Prospective comparative study of third trimester serum retinol binding Protein 4 as a potential adipokine marker of pre-eclampsia
Abstract
Objective: Retinol Binding
Protein–4 (RBP–4) is an adipokine that has been identified as a novel regulator
of insulin resistance. It has been suggested that insulin resistance might be
associated with the pathophysiology of preeclampsia. The aims of this study
were to determine whether the maternal serum levels of RBP-4 differ between
patients with preeclampsia and those with normal pregnancies and to explore the
relationship between the severity of disease and serum concentrations of RBP-4.
Method: This
case-control study included two groups: 1. Patients with preeclampsia (n=27)
and 2. Patients with normal pregnancies (n=27). All subjects enrolled in the
study were in their gestational age of 30 weeks or more. Serum RBP-4
concentrations were determined by ELISA.
Results: Patients with
preeclampsia had a higher serum concentration of RBP-4 than that of normal pregnant women (p < 0.001). When
women with preeclampsia were categorized as those with preeclampsia and severe
preeclampsia, no significant difference was observed in concentration of serum
RBP-4 (p= 0.272).
Conclusions: Our results
support a role of RBP-4 in
the pathogenesis of preeclampsia
References
- 1. Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005; 365: 785–7992. Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179: 1359–1375.3. Chaiworapongsa T, Romero R, Kim YM, Kim GJ, Kim MR, Espinoza J, et al. Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of preeclampsia.J Matern Fetal Neonatal Med 2005;17:3–18.4. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006;355:992–10055. Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 2008;21:9–23.6. Solomon CG, Seely EW. Brief review: hypertension in pregnancy : a manifestation of the insulin resistance syndrome? Hypertension 2001;37:232–239.7.Roberts JM,GammillHS. Preeclampsia: recent insights.Hypertension 2005;46:1243–9.8. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science2005;308:1592–1594.9. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. 2002. Obstet Gynecol 2002; 99:159–167.10. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356–362.11. Zavalza-Gomez AB, et al. Adipokines and insulin resistance during pregnancy.Diabetes Res Clin Pract 2008;80:8–15.12. Vaisbuch E, Romero R, Mazaki-Tovi S, Erez O, Kim KS, Chaiworapongsa T et al. Retinol binding protein 4 - a novel association with early-onset preeclampsia. J Perinat Med 2010, 38(2): 129–139.13. Miehle K, Stepan H and Mathias Fasshauer. Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia. Clinical Endocrinology 2012; 76: 2–11.14.Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006;354:2552–2563.15. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH et al. Plasma Retinol Binding Protein-4 concentrations are elavated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 2006; 29: 2457–2461.16. Chan TF, Chen HS, Chen YC, Lee CH, Chou FH, Chen IJ, et al. Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus. Reprod Sci 2007;14:169–174.17. Klein K, Todesca DB, Leipold H, Knöfler M, Haslinger P, Handisurya A. Retinol Binding Protein 4 in Patients with Gestational Diabetes Mellitus. J of Women’s Health 2010; 19: 517-521.18. Stepan, H., Ebert, T., Schrey, S. et al. Preliminary report: serum levels of retinol-binding protein 4 in preeclampsia. Metabolism 2009; 58: 275–277. [19. Kholy AA, Abadier MZ, Rageh EM, Kallaf HE. Seeum levels of placental growth factor and retinol binding protein-4 in pregnancy induced hypertensive women. J Am Science 2010; 6: 448–455.20. Masuyama, H., Inoue, S. & Hiramatsu, Y. Retinol-binding protein 4 and insulin resistance in preeclampsia. Endocrine Journal, 2011; 58: 47–53.21. Shangguan, X, Liu F, Wang H, He J, Dong M. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clinica Chimica Acta 2009; 407: 58–61.22. Inoue S, Takamoto, N., Akahori, Y, Akahori Y, Masumoto A, Nakatsukasa H. Elevated level of serum retinol-binding protein 4 in pregnancy-induced hypertension.. The Journal of Obstetrics and Gynaecology Research 2009; 35: 293–300.23. Catalano PM, et al. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 1999;180:903–16.24. Barbour LA, et al. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol 2002;186:512–7.25. Nanda, S, Yu, C.K, Giurcaneanu. Maternal serum adiponectin at 11–13 weeks of gestation in preeclampsia. Fetal Diagnosis and Therapy 2011; 29: 208–215.26. Mazaki-Tovi, S., Vaisbuch, E., Romero, R. Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate. The Journal of Maternal-Fetal & Neonatal Medicine 2010; 23: 1119–1128.27. Moore, L.E., Wallace, K.L., Alexander, B.T. Reduced placental perfusion causes an increase in maternal serum leptin. Placenta 2003; 24: 877–881.28. Haffner S. Epidemioliogy of hypertension and insulin resistance syndrome. J hypertens 1997; 15: 25–30. 29. Ferrannini E, Buzzigoli G, Bonadonna R et al. Insulin resistance in essential hypertension. Diabetes Care 2004; 27: 274-275.30. Seol, H.J., Kim, J.W. & Kim, H.J. Retinol-binding protein- 4 is decreased in patients with preeclampsia in comparison with normal pregnant women. Journal of Perinatal Medicine 2011; 39: 287–289.
There are 1 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | June 30, 2019 |
| Acceptance Date | June 10, 2019 |
| Published in Issue | Year 2019Volume: 41 Issue: 2 |