Objective: Retinol Binding
Protein–4 (RBP–4) is an adipokine that has been identified as a novel regulator
of insulin resistance. It has been suggested that insulin resistance might be
associated with the pathophysiology of preeclampsia. The aims of this study
were to determine whether the maternal serum levels of RBP-4 differ between
patients with preeclampsia and those with normal pregnancies and to explore the
relationship between the severity of disease and serum concentrations of RBP-4.
Method: This
case-control study included two groups: 1. Patients with preeclampsia (n=27)
and 2. Patients with normal pregnancies (n=27). All subjects enrolled in the
study were in their gestational age of 30 weeks or more. Serum RBP-4
concentrations were determined by ELISA.
Results: Patients with
preeclampsia had a higher serum concentration of RBP-4 than that of normal pregnant women (p < 0.001). When
women with preeclampsia were categorized as those with preeclampsia and severe
preeclampsia, no significant difference was observed in concentration of serum
RBP-4 (p= 0.272).
Conclusions: Our results
support a role of RBP-4 in
the pathogenesis of preeclampsia
Birincil Dil | İngilizce |
---|---|
Konular | Sağlık Kurumları Yönetimi |
Bölüm | Surgical Science Research Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 30 Haziran 2019 |
Kabul Tarihi | 10 Haziran 2019 |
Yayımlandığı Sayı | Yıl 2019Cilt: 41 Sayı: 2 |