Assessment of the antinociceptive effects of cannabinoid receptor agonists SER 601 and L-759,633 in an acute pain model in rats

Zıad Joha; Şahin Yıldırım; Bülent Saraç

doi:10.7197/cmj.870286

Research Article

Assessment of the antinociceptive effects of cannabinoid receptor agonists SER 601 and L-759,633 in an acute pain model in rats

Year 2021, Volume: 43 Issue: 1, 41 - 48, 31.03.2021

Zıad Joha , Şahin Yıldırım , Bülent Saraç

https://doi.org/10.7197/cmj.870286

Abstract

A poorly managed pain is associated with many negative results. These results disturb patients, their families and societies. Although opioid agents have extraordinary analgesic efficacy, they may cause serious adverse consequences. For medication of pain, there is a medical need to discover possible alternatives to opioids. In animal models of acute pain synthetic cannabinoid receptor agonists demonstrated analgesic effects. Selective activation of the cannabinoid 2 receptor in the rodent models does not cause psychotropic effects therefore CB2R agonists are an appealing target for the medication of pain and other pathologies. In this study we examined the antinociceptive activity of cannabinoid receptor 2 (CB2) agonists SER 601 and L-759,633 in different doses in rat models of acute pain using the hot plate and tail flick tests. These two agents exhibited dose-dependent antinociceptive effects in acute pain model. The analgesic effects of the administrated doses of L-759,633 and SER 601 reached their peak at 60 min. In the tail flick test, the antinociceptive effects of 3, 6 and 12 mg / kg SER601 in the acute pain were more than the L-759,633 groups at the same doses.

Keywords

Acute Pain, Cannabinoid Receptor 2 Agonists, Tail Flick, Hot Plate

Supporting Institution

Cumhuriyet University Scientific Research Project

Project Number

T-848

Thanks

This study was funded by Cumhuriyet University Scientific Research Project (T-848, Doctoral Thesis Project, CUBAP, Turkey).

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