Research Article
Year 2023,
Volume: 45 Issue: 3, 57 - 63, 30.09.2023
Abstract
Supporting Institution
yok
Project Number
yok
Thanks
YOK
References
- 1. Ji P, Zhu J, Feng J, et al. Serum uric acid levels and diabetic kidney disease in patients with type 2 diabetes mellitus: A dose-response meta-analysis. Primary care diabetes. 2022;16(3):457-465.
- 2. Jing Z, Chu J, Imam Syeda Z, et al. Catastrophic health expenditure among type 2 diabetes mellitus patients: A province-wide study in Shandong, China. Journal of diabetes investigation. 2019;10(2):283-289.
- 3. Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses. PloS one. 2018;13(3):e0194127.
- 4. Long AN, Dagogo-Jack S. Comorbidities of diabetes and hypertension: mechanisms and approach to target organ protection. Journal of clinical hypertension (Greenwich, Conn). 2011;13(4):244-251.
- 5. Samsu N. Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment. BioMed research international. 2021;2021:1497449.
- 6. Sternlicht H, Bakris GL. Management of Hypertension in Diabetic Nephropathy: How Low Should We Go? Blood purification. 2016;41(1-3):139-143.
- 7. Bjornstad P, Lanaspa MA, Ishimoto T, et al. Fructose and uric acid in diabetic nephropathy. Diabetologia. 2015;58(9):1993-2002.
- 8. Thipsawat S. Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature. Diabetes & vascular disease research. 2021;18(6):14791641211058856.
- 9. Al-Daghri NM, Al-Attas OS, Wani K, Sabico S, Alokail MS. Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Saudi Type 2 Diabetic Patients. Scientific reports. 2017;7(1):12104.
- 10. Gu L, Huang L, Wu H, Lou Q, Bian R. Serum uric acid to creatinine ratio: A predictor of incident chronic kidney disease in type 2 diabetes mellitus patients with preserved kidney function. Diabetes & vascular disease research. 2017;14(3):221-225.
- 11. Katsiki N, Dimitriadis GD, Mikhailidis DP. Serum Uric Acid and Diabetes: From Pathophysiology to Cardiovascular Disease. Current pharmaceutical design. 2021;27(16):1941-1951.
- 12. Mauer M, Doria A. Uric acid and risk of diabetic kidney disease. Journal of nephrology. 2020;33(5):995-999. 13. Liu L, Gao B, Wang J, et al. Time-averaged serum uric acid and 10-year incident diabetic kidney disease: A prospective study from China. Journal of diabetes. 2020;12(2):169-178.
- 14. Kawamoto R, Ninomiya D, Kikuchi A, et al. Serum uric acid to creatinine ratio is a useful predictor of renal dysfunction among diabetic persons. Diabetes & metabolic syndrome. 2019;13(3):1851-1856.
- 15. Yan D, Tu Y, Jiang F, et al. Uric Acid is independently associated with diabetic kidney disease: a cross-sectional study in a Chinese population. PloS one. 2015;10(6):e0129797.
- 16. Zhu L, Sun J, Wang X, et al. Elevated serum uric acid is not an independent risk factor for the occurrence of Type 2 diabetic kidney disease in Chinese populations. Medicine. 2022;101(50):e32128.
- 17. Kocak MZ, Aktas G, Duman TT, Atak BM, Savli H. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Revista da Associacao Medica Brasileira (1992). 2019;65(9):1155-1160.
- 18. Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes. 2009;58(7):1668-1671.
- 19. Hayashino Y, Okamura S, Tsujii S, Ishii H. Association of serum uric acid levels with the risk of development or progression of albuminuria among Japanese patients with type 2 diabetes: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 10)]. Acta diabetologica. 2016;53(4):599-607.
- 20. Chen L, Zhu Z, Ye S, Zheng M. The Serum Uric Acid to Serum Creatinine Ratio is an Independent Risk Factor for Diabetic Kidney Disease. Diabetes, metabolic syndrome and obesity : targets and therapy. 2022;15:3693-3703.
- 21. Qin Q, Qian Y, Zhu G, Fan W, Niu J, Gu Y. The Correlation between Serum Uric Acid and Renal Function in Elderly Chinese Diabetes with Normoalbuminuria. International journal of endocrinology. 2019;2019:1435875.
- 22. 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021. Diabetes care. 2021;44(Suppl 1):S151-s167.
- 23. Tanaka K, Hara S, Hattori M, et al. Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes. Journal of diabetes investigation. 2015;6(1):98-104.
Is the serum uric acid (SUA) level and SUA/serum creatinine (Scr) ratio a predictive biomarker for microalbuminuria in patients with diabetes mellitus?
Abstract
Background: The pathogenesis of diabetic nephropathy (DN) is very complex and is still not well understood. SUA has been associated with metabolic risk in a wide range of diseases. In this study, we aimed to investigate the effect of SUA and SUA/Scr ratio on renal function using glomerular filtration rate (GFR) and microalbuminuria.
Methods: A total of 399 patients with diabetes alone, excluding other conditions that affect uric acid levels, were included in the study. Patients were divided into normoalbuminuria (n:247) and microalbuminuria (n:152) groups. SUA, SUA/Scr ratios were compared.
Results: Female gender was 53.4% in the normoalbuminuria group and 57.9% in the microalbuminuria group. There was no significant difference in gender between the groups. In the microalbuminuria group, SUA (p=0.032), glucose (p<0.001), GGT (p=0.003), HBA1C (p<0.001), and triglycerides (p<0.001) were significantly higher, while eGFR (p<0.005), HDL (p<0.001), and vitamin D (p=0.017) were significantly lower. There was a significant negative correlation between eGFR and SUA (p<0.001) and albuminuria (p=0.004) and a significant positive correlation between eGFR and SUA/Scr ratio (p<0.001).
Conclusion: Serum uric acid (SUA) levels have been found to be associated with renal function in diabetes. Our study confirms this association. The metabolic and microvascular effects of SUA are widely recognized. Nevertheless, further evidence is required to clarify the relationship between SUA/Scr ratio, which accounts for renal function, and DN.
Project Number
yok
References
- 1. Ji P, Zhu J, Feng J, et al. Serum uric acid levels and diabetic kidney disease in patients with type 2 diabetes mellitus: A dose-response meta-analysis. Primary care diabetes. 2022;16(3):457-465.
- 2. Jing Z, Chu J, Imam Syeda Z, et al. Catastrophic health expenditure among type 2 diabetes mellitus patients: A province-wide study in Shandong, China. Journal of diabetes investigation. 2019;10(2):283-289.
- 3. Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses. PloS one. 2018;13(3):e0194127.
- 4. Long AN, Dagogo-Jack S. Comorbidities of diabetes and hypertension: mechanisms and approach to target organ protection. Journal of clinical hypertension (Greenwich, Conn). 2011;13(4):244-251.
- 5. Samsu N. Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment. BioMed research international. 2021;2021:1497449.
- 6. Sternlicht H, Bakris GL. Management of Hypertension in Diabetic Nephropathy: How Low Should We Go? Blood purification. 2016;41(1-3):139-143.
- 7. Bjornstad P, Lanaspa MA, Ishimoto T, et al. Fructose and uric acid in diabetic nephropathy. Diabetologia. 2015;58(9):1993-2002.
- 8. Thipsawat S. Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature. Diabetes & vascular disease research. 2021;18(6):14791641211058856.
- 9. Al-Daghri NM, Al-Attas OS, Wani K, Sabico S, Alokail MS. Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Saudi Type 2 Diabetic Patients. Scientific reports. 2017;7(1):12104.
- 10. Gu L, Huang L, Wu H, Lou Q, Bian R. Serum uric acid to creatinine ratio: A predictor of incident chronic kidney disease in type 2 diabetes mellitus patients with preserved kidney function. Diabetes & vascular disease research. 2017;14(3):221-225.
- 11. Katsiki N, Dimitriadis GD, Mikhailidis DP. Serum Uric Acid and Diabetes: From Pathophysiology to Cardiovascular Disease. Current pharmaceutical design. 2021;27(16):1941-1951.
- 12. Mauer M, Doria A. Uric acid and risk of diabetic kidney disease. Journal of nephrology. 2020;33(5):995-999. 13. Liu L, Gao B, Wang J, et al. Time-averaged serum uric acid and 10-year incident diabetic kidney disease: A prospective study from China. Journal of diabetes. 2020;12(2):169-178.
- 14. Kawamoto R, Ninomiya D, Kikuchi A, et al. Serum uric acid to creatinine ratio is a useful predictor of renal dysfunction among diabetic persons. Diabetes & metabolic syndrome. 2019;13(3):1851-1856.
- 15. Yan D, Tu Y, Jiang F, et al. Uric Acid is independently associated with diabetic kidney disease: a cross-sectional study in a Chinese population. PloS one. 2015;10(6):e0129797.
- 16. Zhu L, Sun J, Wang X, et al. Elevated serum uric acid is not an independent risk factor for the occurrence of Type 2 diabetic kidney disease in Chinese populations. Medicine. 2022;101(50):e32128.
- 17. Kocak MZ, Aktas G, Duman TT, Atak BM, Savli H. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Revista da Associacao Medica Brasileira (1992). 2019;65(9):1155-1160.
- 18. Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes. 2009;58(7):1668-1671.
- 19. Hayashino Y, Okamura S, Tsujii S, Ishii H. Association of serum uric acid levels with the risk of development or progression of albuminuria among Japanese patients with type 2 diabetes: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 10)]. Acta diabetologica. 2016;53(4):599-607.
- 20. Chen L, Zhu Z, Ye S, Zheng M. The Serum Uric Acid to Serum Creatinine Ratio is an Independent Risk Factor for Diabetic Kidney Disease. Diabetes, metabolic syndrome and obesity : targets and therapy. 2022;15:3693-3703.
- 21. Qin Q, Qian Y, Zhu G, Fan W, Niu J, Gu Y. The Correlation between Serum Uric Acid and Renal Function in Elderly Chinese Diabetes with Normoalbuminuria. International journal of endocrinology. 2019;2019:1435875.
- 22. 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021. Diabetes care. 2021;44(Suppl 1):S151-s167.
- 23. Tanaka K, Hara S, Hattori M, et al. Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes. Journal of diabetes investigation. 2015;6(1):98-104.
There are 22 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Multimorbidity |
| Journal Section | Medical Science Research Articles |
| Authors | |
| Project Number | yok |
| Publication Date | September 30, 2023 |
| Acceptance Date | September 26, 2023 |
| Published in Issue | Year 2023Volume: 45 Issue: 3 |
