Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Zehra Dilşad Çoban; Tuna Karaer; Büşra Atmaca; Halide Kaya Demir; Şefik Güran

doi:10.7197/223.v39i31705.347452

EN TR

Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Abstract

Objective: Usnic acid is a secondary metabolite in lichens whose role has not been completely elucidated. Lichen extracts containing usnic acid have been utilized in medicine, perfumery, cosmetics, and ecology. Usnic asit inhibits cell growth, induces the cell cycle arrest and apoptosis in human lung carcinoma.

Methods:Herein we analyzed the antitumoral effect of usnic acid on the same cell line. We analyzed the gene expression results on APOPT1, CYCS, APAF1, CASP3/9, TNF, BCL2, BCL2L1 and AIFM1 genes which have possible role on cell apopitosis.

Results: Usnic acid has stimulatory effect on APOPT1, CYCS, APAF1, CASP3, CASP9 gene expressions in our experiments.

Conclusion: Usnic acid has antitumoral effect on cancer cells, affecting on mithocondrial apopitotic genes.

Keywords

Usnic acid,cell growth,apopitosis,gene,antitumoral affect

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Zehra Dilşad Çoban

Tuna Karaer

Büşra Atmaca

Halide Kaya Demir

Şefik Güran

Yayımlanma Tarihi

19 Eylül 2017

Gönderilme Tarihi

10 Nisan 2017

Kabul Tarihi

1 Haziran 2017

Yayımlandığı Sayı

Yıl 1970 Cilt: 39 Sayı: 3

DOI

https://doi.org/10.7197/223.v39i31705.347452

IZ

https://izlik.org/JA36YP66NN

Kaynak Göster

RIS / Bibtex

AMA

1.Çoban ZD, Karaer T, Atmaca B, Kaya Demir H, Güran Ş. Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role. CMJ. 2017;39(3):539-545. doi:10.7197/223.v39i31705.347452

Cited By

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

Molecules

https://doi.org/10.3390/molecules25081865

Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens

Frontiers in Cellular Neuroscience

https://doi.org/10.3389/fncel.2022.907308

Usnik asitin tümör önleyici rolü mitokondrial apopitotik yolak üzerindedir

Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Abstract

Keywords

Usnik asitin tümör önleyici rolü mitokondrial apopitotik yolak üzerindedir

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens