Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Zehra Dilşad Çoban; Tuna Karaer; Büşra Atmaca; Halide Kaya Demir; Şefik Güran

doi:10.7197/223.v39i31705.347452

EN TR

Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Abstract

Objective: Usnic acid is a secondary metabolite in lichens whose role has not been completely elucidated. Lichen extracts containing usnic acid have been utilized in medicine, perfumery, cosmetics, and ecology. Usnic asit inhibits cell growth, induces the cell cycle arrest and apoptosis in human lung carcinoma.

Methods:Herein we analyzed the antitumoral effect of usnic acid on the same cell line. We analyzed the gene expression results on APOPT1, CYCS, APAF1, CASP3/9, TNF, BCL2, BCL2L1 and AIFM1 genes which have possible role on cell apopitosis.

Results: Usnic acid has stimulatory effect on APOPT1, CYCS, APAF1, CASP3, CASP9 gene expressions in our experiments.

Conclusion: Usnic acid has antitumoral effect on cancer cells, affecting on mithocondrial apopitotic genes.

Keywords

Usnic acid,cell growth,apopitosis,gene,antitumoral affect

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Zehra Dilşad Çoban

Tuna Karaer

Büşra Atmaca

Halide Kaya Demir

Şefik Güran

Publication Date

September 19, 2017

Submission Date

April 10, 2017

Acceptance Date

June 1, 2017

Published in Issue

Year 1970 Volume: 39 Number: 3

DOI

https://doi.org/10.7197/223.v39i31705.347452

IZ

https://izlik.org/JA36YP66NN

Cite

RIS / Bibtex

AMA

1.Çoban ZD, Karaer T, Atmaca B, Kaya Demir H, Güran Ş. Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role. CMJ. 2017;39(3):539-545. doi:10.7197/223.v39i31705.347452

Cited By

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

Molecules

https://doi.org/10.3390/molecules25081865

Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens

Frontiers in Cellular Neuroscience

https://doi.org/10.3389/fncel.2022.907308

Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role

Abstract

Keywords

Usnik asitin tümör önleyici rolü mitokondrial apopitotik yolak üzerindedir

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens