Decellularization of tissues and organs

Nevra Pelin Cesur; Volkan Yalman; Nelisa Laçin Türkoğlu

doi:10.7197/cmj.vi.609592

TR EN

Decellularization of tissues and organs

Abstract

Decellularized tissues and organs have been successfully used in various tissue engineering and regenerative medicine applications. A biological scaffold obtained from the extracellular matrix can be produced by a variety of decellularization methods that effectively remove cells from the tissue to be treated. Decellularization methods is changed according to the target structure of tissues and organs. These methods can be summarized with chemically, physically, enzymatically and using Supercritical Fluid Extraction (SFE) ways. Each of these methods affects the biochemical composition in the structure of the remaining extracellular matrix (ECM), the structure of the tissue (ultrastructure), and the mechanical behavior. In this article, the most commonly used decellulization methods are introduced and their effects on biological tissue scaffold materials are discussed.

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Kaynakça

4. REFERENCES
1. Antons, J., Marascio, M. G. M., Aeberhard, P., Weissenberger, G., Hirt-Burri, N., Applegate, L. A., … Pioletti, D. P. (2018). Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2. European Cells and Materials, 36, 81–95. https://doi.org/10.22203/eCM.v036a07
2. Berthiaume, F., Maguire, T. J., & Yarmush, M. L. (2011). Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges. Annual Review of Chemical and Biomolecular Engineering. https://doi.org/10.1146/annurev-chembioeng-061010-114257
3. Casali, D. M., Handleton, R. M., Shazly, T., & Matthews, M. A. (2018). A novel supercritical CO2-based decellularization method for maintaining scaffold hydration and mechanical properties. Journal of Supercritical Fluids, 131, 72–81. https://doi.org/10.1016/j.supflu.2017.07.021
4. Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011). An overview of tissue and whole organ decellularization processes. Biomaterials. https://doi.org/10.1016/j.biomaterials.2011.01.057
5. Çeviker, K., Özcan Özseven, S., Gülnihal Şeker, C., Rahim, M., Kılıçarslan, Ş., Yazkan, R., ve Damar, K. (n.d.). Biyolojik damarsal greft üretiminde hücresizleştirme metodları; güncel literatür derlemesi The decellularization methodologies for the production of biologic vascular graft; an updated literature review.
6. Eckert, C. A., Knutson, B. L., & Debenedetti, P. G. (1996). Supercritical fluids as solvents for chemical and materials processing. Nature. https://doi.org/10.1038/383313a0
7. Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006). Decellularization of tissues and organs. Biomaterials. https://doi.org/10.1016/j.biomaterials.2006.02.014

8. Gilbert, T. W., Wognum, S., Joyce, E. M., Freytes, D. O., Sacks, M. S., & Badylak, S. F. (2008). Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix. Biomaterials. https://doi.org/10.1016/j.biomaterials.2008.08.022
9. Gilpin, A., & Yang, Y. (2017). Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications. BioMed Research International. https://doi.org/10.1155/2017/9831534
10. Guler, S., Aslan, B., Hosseinian, P., & Aydin, H. M. (2017). Supercritical Carbon Dioxide-Assisted Decellularization of Aorta and Cornea. Tissue Engineering Part C: Methods, 23(9), 540–547. https://doi.org/10.1089/ten.tec.2017.0090
11. Halfwerk, F. R., Rouwkema, J., Gossen, J. A., & Grandjean, J. G. (2018). Supercritical carbon dioxide decellularised pericardium: Mechanical and structural characterisation for applications in cardio-thoracic surgery. Journal of the Mechanical Behavior of Biomedical Materials, 77, 400–407. https://doi.org/10.1016/j.jmbbm.2017.10.002
12. Hodde, J., & Hiles, M. (2002). Virus safety of a porcine-derived medical device: Evaluation of a viral inactivation method. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.10281
13. Hortensius, R. A., & Harley, B. A. C. (2016). Naturally derived biomaterials for addressing inflammation in tissue regeneration. Experimental Biology and Medicine. https://doi.org/10.1177/1535370216648022
14. Jackson, D. W., Grood, E. S., Cohn, B. T., Arnoczky, S. P., Simon, T. M., & Cummings, J. F. (1991). The effects of in situ freezing on the anterior cruciate ligament: An experimental study in goats. Journal of Bone and Joint Surgery - Series A. https://doi.org/10.2106/00004623-199173020-00008
15. Katsimpoulas, M., Morticelli, L., Michalopoulos, E., Gontika, I., Stavropoulos-Giokas, C., Kostakis, A., … Korossis, S. (2015). Investigation of the biomechanical integrity of decellularized rat abdominal aorta. Transplantation Proceedings. https://doi.org/10.1016/j.transproceed.2014.11.061
16. Ott, H. C., Matthiesen, T. S., Goh, S. K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008). Perfusion-decellularized matrix: Using nature’s platform to engineer a bioartificial heart. Nature Medicine. https://doi.org/10.1038/nm1684
17. Petrosyan, A., Da Sacco, S., Tripuraneni, N., Kreuser, U., Lavarreda-Pearce, M., Tamburrini, R., Perin, L. (2017). A step towards clinical application of acellular matrix: A clue from macrophage polarization. Matrix Biology. https://doi.org/10.1016/j.matbio.2016.08.009
18. Sawada, K., Terada, D., Yamaoka, T., Kitamura, S., & Fujisato, T. (2008). Cell removal with supercritical carbon dioxide for acellular artificial tissue. Journal of Chemical Technology and Biotechnology. https://doi.org/10.1002/jctb.1899
19. Schenke-Layland, K., Vasilevski, O., Opitz, F., König, K., Riemann, I., Halbhuber, K. J., … Stock, U. A. (2003). Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves. Journal of Structural Biology. https://doi.org/10.1016/j.jsb.2003.08.002
20. Seddon, A. M., Curnow, P., & Booth, P. J. (2004). Membrane proteins, lipids and detergents: Not just a soap opera. Biochimica et Biophysica Acta - Biomembranes. https://doi.org/10.1016/j.bbamem.2004.04.011
21. Syazwani, N., Azhim, A., Morimoto, Y., Furukawa, K. S., & Ushida, T. (2015). Decellularization of aorta tissue using sonication treatment as potential scaffold for vascular tissue engineering. Journal of Medical and Biological Engineering. https://doi.org/10.1007/s40846-015-0028-5
22. Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016). Extracellular matrix structure. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2015.11.001
23. Üçgül, İ., & Aras, S. (2017). ANKA e-DERGİ Journal of Phoenix DESELÜLERİZASYON YÖNTEMLERİ VE DOKULARDA KULLANIMI.
24. Voet, D., Voet, J. G., & Pratt, C. W. (2016). Fundamentals of biochemistry life at the molecular level. In Fundamentals of biochemistry life at the molecular level.
25. Xing, Q., Yates, K., Tahtinen, M., Shearier, E., Qian, Z., & Zhao, F. (2015). Decellularization of fibroblast cell sheets for natural extracellular matrix scaffold preparation. Tissue Engineering - Part C: Methods. https://doi.org/10.1089/ten.tec.2013.0666
26. Xu, H., Xu, B., Yang, Q., Li, X., Ma, X., Xia, Q., Zhang, Y. (2014). Comparison of decellularization protocols for preparing a decellularized porcine annulus fibrosus scaffold. PLoS ONE. https://doi.org/10.1371/journal.pone.0086723

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Nevra Pelin Cesur
0000-0003-3979-6053
Türkiye

Volkan Yalman
0000-0001-8267-9712
Türkiye

Nelisa Laçin Türkoğlu ^*
0000-0003-3176-0902
Türkiye

Yayımlanma Tarihi

21 Temmuz 2020

Gönderilme Tarihi

22 Ağustos 2019

Kabul Tarihi

6 Temmuz 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 42 Sayı: 2

DOI

https://doi.org/10.7197/cmj.vi.609592

IZ

https://izlik.org/JA32KY94SS

Kaynak Göster

RIS / Bibtex

AMA

1.Cesur NP, Yalman V, Laçin Türkoğlu N. Decellularization of tissues and organs. CMJ. 2020;42(2):192-197. doi:10.7197/cmj.vi.609592

Decellularization of tissues and organs

Dokuların ve organların hücresizleştirilmesi

Öz

Anahtar Kelimeler

Decellularization of tissues and organs

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster