Araştırma Makalesi
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Yıl 2019, , 551 - 557, 30.09.2019
https://doi.org/10.7197/cmj.vi.623582

Öz

Kaynakça

  • [1] Yang Y, Asiri A M, Tang Z, Du D, Lin Y. Graphene based materials for biomedical applications. Mater Today 2013; 16: 365-373.
  • [2] Nanda S S, Papaefthymiou G C, Yi D K. Functionalization of Graphene Oxide and its Biomedical Applications. Crit Rev Solid State 2015; 40: 291-315.
  • [3] Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D. Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy. Theranostics 2011; 1: 240-250.
  • [4] Li Y, Dong H, Li Y, Shi D. Graphene-based nanovehicles for photodynamic medical therapy. Int J Nanomed 2015; 10: 2451-2459.
  • [5] Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J. Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photoch Photobio B 2014; 135: 7-16.
  • [6] Shen H, Zhang L, Liu M, Zhang Z. Biomedical Applications of Graphene. Theranostics 2012; 2: 283-294.
  • [7] Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques‑Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali A M. The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nano 2017; 8: 1-62.
  • [8] Tabisha T A, Zhanga S, Winyard P G. Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species. Redox Biol 2018; 15: 34-40.
  • [9] Krajczewski J, Ruci´nska K, Townley H E, Kudelski A. Role of various nanoparticles in photodynamic therapy and detection methods of singlet oxygen. Photodiag Photodyn Therapy 2019; 26: 162-178.
  • [10] Nene L C, Managa M, Nyokong T. Photo-physicochemical properties and in vitro photodynamic therapy activity of morpholine-substituted Zinc(II)-Phthalocyanines π-π stacked on biotinylated graphene quantum dots. Dyes Pigments 2019; 165: 488-498.
  • [11] Jinling H, Naisheng C, Jiandong H, Ersheng L, Jinping X, Suling Y, Ziqiang H, Jiancheng S. Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT). Sci In China (Series B) 2001; 44: 113-122.
  • [12] Lukyanets E A. Phthalocyanines as Photosensitizers in the Photodynamic Therapy of Cancer. J Porph Phthalocya 1999; 3: 424-432.
  • [13] Figueiraa F, Pereiraa P M R, Silvaa S, Cavaleiroa J AS, Tomé J P C, Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications. Curr Org Synth 2014; 11: 110-126.
  • [14] Mody T D. Pharmaceutical development and medical applications of porphyrin‐type macrocycles. J Porph Phthalocya 2000; 4: 362-367.
  • [15] Li X, Zheng B D, Peng X H, Li S Z, Ying J W, Zhao Y, Huang J D, Yoon J. Phthalocyanines as medicinal photosensitizers: Developments in the lastfive years. Coord. Chem. Rev 2019; 379: 147-160.
  • [16] Boas U, Heegaard P M H. Dendrimers in drug research. Chem Soc Rev 2004, 33(1), 43-63.
  • [17] Medina S H, El-Sayed M E H. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009; 109(7): 3141-3157.
  • [18] Tekade R K, Kumar P V, Jain N K. Dendrimers in oncology: an expanding horizon. Chem Rev 2010; 110(4): 2574-2574.
  • [19] Jeong Y H, Yoon H J, Jang W D. Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications. Polymer J 2012; 44: 512-521.
  • [20] Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel University J Natur Appl Sci 2017; 21: 689-695.

New generation graphene-based dendritic phthalocyanine: Potential usage for biomedical applications

Yıl 2019, , 551 - 557, 30.09.2019
https://doi.org/10.7197/cmj.vi.623582

Öz

Objective: It is aimed to produce new graphene-based materials with potential used in
biomedical applications.

Method: The new
GO-ZnPc hybrid was obtained by self-assembly method. Sonication was performed
in the formation of hybrid.
UV-Vis, emission spectra and scanning
electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation.

Results: The GO solutions of different concentrations
(0.0005 µg / mL; 0.005 µg / mL; 0.05 µg / mL; 0.4 µg / mL; 0.7 µg / mL; 1 µg /
mL) prepared by sonication were added to 10 µg / mL ZnPc solution separately
and sonicated again.
UV-Vis, emission spectra and scanning
electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation. All measurements showed that intermolecular interactions
occurred after mixing the two components together, and the resulting hybrid was
stable.







Conclusions: In
this study, the new ZnPc-GO hybrid prepared and
characterized. ZnPc and GO derivative was observed to well-coordinated. The
obtained hybrid system was observed to have very interesting spectroscopic
properties. It was observed that the GO-based ZnPc hybrid gave an absorption
peak at 716 nm in the UV-Vis spectrum. The redshift observed with the ZnPc-GO
hybrid formation in the UV spectra indicates that this material has the
potential to be used in many biomedical applications, especially in tissue engineering and photodynamic
therapy. 

Kaynakça

  • [1] Yang Y, Asiri A M, Tang Z, Du D, Lin Y. Graphene based materials for biomedical applications. Mater Today 2013; 16: 365-373.
  • [2] Nanda S S, Papaefthymiou G C, Yi D K. Functionalization of Graphene Oxide and its Biomedical Applications. Crit Rev Solid State 2015; 40: 291-315.
  • [3] Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D. Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy. Theranostics 2011; 1: 240-250.
  • [4] Li Y, Dong H, Li Y, Shi D. Graphene-based nanovehicles for photodynamic medical therapy. Int J Nanomed 2015; 10: 2451-2459.
  • [5] Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J. Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photoch Photobio B 2014; 135: 7-16.
  • [6] Shen H, Zhang L, Liu M, Zhang Z. Biomedical Applications of Graphene. Theranostics 2012; 2: 283-294.
  • [7] Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques‑Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali A M. The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nano 2017; 8: 1-62.
  • [8] Tabisha T A, Zhanga S, Winyard P G. Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species. Redox Biol 2018; 15: 34-40.
  • [9] Krajczewski J, Ruci´nska K, Townley H E, Kudelski A. Role of various nanoparticles in photodynamic therapy and detection methods of singlet oxygen. Photodiag Photodyn Therapy 2019; 26: 162-178.
  • [10] Nene L C, Managa M, Nyokong T. Photo-physicochemical properties and in vitro photodynamic therapy activity of morpholine-substituted Zinc(II)-Phthalocyanines π-π stacked on biotinylated graphene quantum dots. Dyes Pigments 2019; 165: 488-498.
  • [11] Jinling H, Naisheng C, Jiandong H, Ersheng L, Jinping X, Suling Y, Ziqiang H, Jiancheng S. Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT). Sci In China (Series B) 2001; 44: 113-122.
  • [12] Lukyanets E A. Phthalocyanines as Photosensitizers in the Photodynamic Therapy of Cancer. J Porph Phthalocya 1999; 3: 424-432.
  • [13] Figueiraa F, Pereiraa P M R, Silvaa S, Cavaleiroa J AS, Tomé J P C, Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications. Curr Org Synth 2014; 11: 110-126.
  • [14] Mody T D. Pharmaceutical development and medical applications of porphyrin‐type macrocycles. J Porph Phthalocya 2000; 4: 362-367.
  • [15] Li X, Zheng B D, Peng X H, Li S Z, Ying J W, Zhao Y, Huang J D, Yoon J. Phthalocyanines as medicinal photosensitizers: Developments in the lastfive years. Coord. Chem. Rev 2019; 379: 147-160.
  • [16] Boas U, Heegaard P M H. Dendrimers in drug research. Chem Soc Rev 2004, 33(1), 43-63.
  • [17] Medina S H, El-Sayed M E H. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009; 109(7): 3141-3157.
  • [18] Tekade R K, Kumar P V, Jain N K. Dendrimers in oncology: an expanding horizon. Chem Rev 2010; 110(4): 2574-2574.
  • [19] Jeong Y H, Yoon H J, Jang W D. Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications. Polymer J 2012; 44: 512-521.
  • [20] Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel University J Natur Appl Sci 2017; 21: 689-695.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Medical Science Research Makaleler
Yazarlar

Ebru Yabaş 0000-0001-7163-3057

Yayımlanma Tarihi 30 Eylül 2019
Kabul Tarihi 30 Eylül 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

AMA Yabaş E. New generation graphene-based dendritic phthalocyanine: Potential usage for biomedical applications. CMJ. Eylül 2019;41(3):551-557. doi:10.7197/cmj.vi.623582