Araştırma Makalesi
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Yıl 2019, , 551 - 557, 30.09.2019

Ebru Yabaş

https://doi.org/10.7197/cmj.vi.623582

Öz

Kaynakça

  • [1] Yang Y, Asiri A M, Tang Z, Du D, Lin Y. Graphene based materials for biomedical applications. Mater Today 2013; 16: 365-373.
  • [2] Nanda S S, Papaefthymiou G C, Yi D K. Functionalization of Graphene Oxide and its Biomedical Applications. Crit Rev Solid State 2015; 40: 291-315.
  • [3] Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D. Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy. Theranostics 2011; 1: 240-250.
  • [4] Li Y, Dong H, Li Y, Shi D. Graphene-based nanovehicles for photodynamic medical therapy. Int J Nanomed 2015; 10: 2451-2459.
  • [5] Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J. Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photoch Photobio B 2014; 135: 7-16.
  • [6] Shen H, Zhang L, Liu M, Zhang Z. Biomedical Applications of Graphene. Theranostics 2012; 2: 283-294.
  • [7] Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques‑Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali A M. The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nano 2017; 8: 1-62.
  • [8] Tabisha T A, Zhanga S, Winyard P G. Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species. Redox Biol 2018; 15: 34-40.
  • [9] Krajczewski J, Ruci´nska K, Townley H E, Kudelski A. Role of various nanoparticles in photodynamic therapy and detection methods of singlet oxygen. Photodiag Photodyn Therapy 2019; 26: 162-178.
  • [10] Nene L C, Managa M, Nyokong T. Photo-physicochemical properties and in vitro photodynamic therapy activity of morpholine-substituted Zinc(II)-Phthalocyanines π-π stacked on biotinylated graphene quantum dots. Dyes Pigments 2019; 165: 488-498.
  • [11] Jinling H, Naisheng C, Jiandong H, Ersheng L, Jinping X, Suling Y, Ziqiang H, Jiancheng S. Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT). Sci In China (Series B) 2001; 44: 113-122.
  • [12] Lukyanets E A. Phthalocyanines as Photosensitizers in the Photodynamic Therapy of Cancer. J Porph Phthalocya 1999; 3: 424-432.
  • [13] Figueiraa F, Pereiraa P M R, Silvaa S, Cavaleiroa J AS, Tomé J P C, Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications. Curr Org Synth 2014; 11: 110-126.
  • [14] Mody T D. Pharmaceutical development and medical applications of porphyrin‐type macrocycles. J Porph Phthalocya 2000; 4: 362-367.
  • [15] Li X, Zheng B D, Peng X H, Li S Z, Ying J W, Zhao Y, Huang J D, Yoon J. Phthalocyanines as medicinal photosensitizers: Developments in the lastfive years. Coord. Chem. Rev 2019; 379: 147-160.
  • [16] Boas U, Heegaard P M H. Dendrimers in drug research. Chem Soc Rev 2004, 33(1), 43-63.
  • [17] Medina S H, El-Sayed M E H. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009; 109(7): 3141-3157.
  • [18] Tekade R K, Kumar P V, Jain N K. Dendrimers in oncology: an expanding horizon. Chem Rev 2010; 110(4): 2574-2574.
  • [19] Jeong Y H, Yoon H J, Jang W D. Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications. Polymer J 2012; 44: 512-521.
  • [20] Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel University J Natur Appl Sci 2017; 21: 689-695.

New generation graphene-based dendritic phthalocyanine: Potential usage for biomedical applications

Yıl 2019, , 551 - 557, 30.09.2019

Ebru Yabaş

https://doi.org/10.7197/cmj.vi.623582

Öz

Objective: It is aimed to produce new graphene-based materials with potential used in
biomedical applications.

Method: The new
GO-ZnPc hybrid was obtained by self-assembly method. Sonication was performed
in the formation of hybrid. UV-Vis, emission spectra and scanning
electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation.

Results: The GO solutions of different concentrations
(0.0005 µg / mL; 0.005 µg / mL; 0.05 µg / mL; 0.4 µg / mL; 0.7 µg / mL; 1 µg /
mL) prepared by sonication were added to 10 µg / mL ZnPc solution separately
and sonicated again. UV-Vis, emission spectra and scanning
electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation. All measurements showed that intermolecular interactions
occurred after mixing the two components together, and the resulting hybrid was
stable.







Conclusions: In
this study, the new ZnPc-GO hybrid prepared and
characterized. ZnPc and GO derivative was observed to well-coordinated. The
obtained hybrid system was observed to have very interesting spectroscopic
properties. It was observed that the GO-based ZnPc hybrid gave an absorption
peak at 716 nm in the UV-Vis spectrum. The redshift observed with the ZnPc-GO
hybrid formation in the UV spectra indicates that this material has the
potential to be used in many biomedical applications, especially in tissue engineering and photodynamic
therapy. 

Anahtar Kelimeler

Graphene oxide phthalocyanine dendrimer biomedical application

Kaynakça

  • [1] Yang Y, Asiri A M, Tang Z, Du D, Lin Y. Graphene based materials for biomedical applications. Mater Today 2013; 16: 365-373.
  • [2] Nanda S S, Papaefthymiou G C, Yi D K. Functionalization of Graphene Oxide and its Biomedical Applications. Crit Rev Solid State 2015; 40: 291-315.
  • [3] Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D. Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy. Theranostics 2011; 1: 240-250.
  • [4] Li Y, Dong H, Li Y, Shi D. Graphene-based nanovehicles for photodynamic medical therapy. Int J Nanomed 2015; 10: 2451-2459.
  • [5] Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J. Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photoch Photobio B 2014; 135: 7-16.
  • [6] Shen H, Zhang L, Liu M, Zhang Z. Biomedical Applications of Graphene. Theranostics 2012; 2: 283-294.
  • [7] Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques‑Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali A M. The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nano 2017; 8: 1-62.
  • [8] Tabisha T A, Zhanga S, Winyard P G. Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species. Redox Biol 2018; 15: 34-40.
  • [9] Krajczewski J, Ruci´nska K, Townley H E, Kudelski A. Role of various nanoparticles in photodynamic therapy and detection methods of singlet oxygen. Photodiag Photodyn Therapy 2019; 26: 162-178.
  • [10] Nene L C, Managa M, Nyokong T. Photo-physicochemical properties and in vitro photodynamic therapy activity of morpholine-substituted Zinc(II)-Phthalocyanines π-π stacked on biotinylated graphene quantum dots. Dyes Pigments 2019; 165: 488-498.
  • [11] Jinling H, Naisheng C, Jiandong H, Ersheng L, Jinping X, Suling Y, Ziqiang H, Jiancheng S. Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT). Sci In China (Series B) 2001; 44: 113-122.
  • [12] Lukyanets E A. Phthalocyanines as Photosensitizers in the Photodynamic Therapy of Cancer. J Porph Phthalocya 1999; 3: 424-432.
  • [13] Figueiraa F, Pereiraa P M R, Silvaa S, Cavaleiroa J AS, Tomé J P C, Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications. Curr Org Synth 2014; 11: 110-126.
  • [14] Mody T D. Pharmaceutical development and medical applications of porphyrin‐type macrocycles. J Porph Phthalocya 2000; 4: 362-367.
  • [15] Li X, Zheng B D, Peng X H, Li S Z, Ying J W, Zhao Y, Huang J D, Yoon J. Phthalocyanines as medicinal photosensitizers: Developments in the lastfive years. Coord. Chem. Rev 2019; 379: 147-160.
  • [16] Boas U, Heegaard P M H. Dendrimers in drug research. Chem Soc Rev 2004, 33(1), 43-63.
  • [17] Medina S H, El-Sayed M E H. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009; 109(7): 3141-3157.
  • [18] Tekade R K, Kumar P V, Jain N K. Dendrimers in oncology: an expanding horizon. Chem Rev 2010; 110(4): 2574-2574.
  • [19] Jeong Y H, Yoon H J, Jang W D. Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications. Polymer J 2012; 44: 512-521.
  • [20] Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel University J Natur Appl Sci 2017; 21: 689-695.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Medical Science Research Makaleler
Yazarlar

Ebru Yabaş 0000-0001-7163-3057

Yayımlanma Tarihi 30 Eylül 2019
Kabul Tarihi 30 Eylül 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

AMA Yabaş E. New generation graphene-based dendritic phthalocyanine: Potential usage for biomedical applications. CMJ. Eylül 2019;41(3):551-557. doi:10.7197/cmj.vi.623582