Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2018, Cilt: 40 Sayı: 4, 334 - 345, 29.12.2018
https://doi.org/10.7197/223.vi.498239

Öz

Kaynakça

  • Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.

DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE

Yıl 2018, Cilt: 40 Sayı: 4, 334 - 345, 29.12.2018
https://doi.org/10.7197/223.vi.498239

Öz

Hypertension, defined
as high blood pressure, is a common medical condition leading to cardiovascular
disability and premature deaths. Blood pressure control in an efficient way are
assumed to the main targets to prevent hypertension. Since conventional dosage
forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater
attention is being paid on designing the modified drug release systems.
Modified release is defined as drug releasing from dosage form some time after
the administration or in prolonged period of time. In this study, we aimed to
design metoprolol tartarate loaded chitosan microparticles to obtained modified
drug release. Chitosan microparticles produced via ionic gelation with
tripolyphosphate as a crosslinking agent. Prepared formulations were characterized
and metoprolol tartarate was loaded into the optimal blank microspheres. The
entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated.
Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm
particle size. 16 mg of metoprolol tartarate could be loaded into
microparticles and drug release could be maintained for 48 hours.

Kaynakça

  • Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Temel Tıp Bilimleri Araştırma Yazıları
Yazarlar

Gülen Melike Demırbolat

Cenk Yıldız

Mustafa Ergül

Yayımlanma Tarihi 29 Aralık 2018
Kabul Tarihi 23 Aralık 2018
Yayımlandığı Sayı Yıl 2018Cilt: 40 Sayı: 4

Kaynak Göster

AMA Demırbolat GM, Yıldız C, Ergül M. DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE. CMJ. Aralık 2018;40(4):334-345. doi:10.7197/223.vi.498239