Fruktoz ve böbrek hastalıkları

İpek Kaplan Bulut; Sevgi Mir

Fruktoz ve böbrek hastalıkları

Yıl 2011, Cilt: 33 Sayı: 4, 499 - 507, 29.06.2011

İpek Kaplan Bulut Sevgi Mir

Öz

Özet

Fruktoz tüketimi; yüksek fruktozlu mısır şurubu ya da sukroz olacak şekilde günlük beslenmemizde özellikle son yıllarda artmıştır. Modern dünyada çocukluk ve gençlik döneminde mısır kaynaklı fruktozla yapılan yiyecek içecek tüketimi önemli bir yer almaktadır. Yüksek fruktozlu besinler özellikle fiziksel hareketsizlik ve tüketim fazlalığı ile birlikte, kronik hastalıkların (hipertansiyon, obesite, metabolik sendrom, böbrek hastalığı, taş) gelişiminde önemli bir rol oynayabilir. Bu yazıda fruktozdan zenginleştirilmiş işlenmiş gıdaların, böbrek hastalıkları ile ilişkisinden bahsedilmiştir.

Anahtar sözcükler: Fruktoz, böbrek, beslenme

Abstract

Fructose consumption has increased in recent years especially as high fructose corn syrup or sucrose in daily nutrition. Food and beverage consumption with made from fructose is an important during the period of childhood and youth in the modern world. High-fructose foods, specifically together with physical inactivity and excess consumption, may be play an development of chronic diseases such as hypertension, obesity, metabolic syndrome and kidney disease. In this article, processed foods enriched with fructose the effect of kidney diseases are discussed.

Keywords: Fructose, kidney, nutrition

Anahtar Kelimeler

Kaynakça

Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sánchez-Lozada LG. Dietary fructose and hypertension. Curr Hypertens Rep 2011; 13: 29-35.
Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007; 86: 899-906.
Kizhner T, Werman MJ. Long-term fructose intake: biochemical consequences and altered renal histology in the male rat. Metabolism 2002; 51: 1538-47.
Korkmaz A. Fruktoz; Kronik Hastalıklar İçin Gizli Bir Tehdit. TAF Prev Med Bull 2008; 7: 343-6.
Tam CS, Garnett SP, Cowell CT, Campbell K, Cabrera G, Baur LA. Soft drink consumption and excess weight gain in Australian school students: results from the Nepean study. Int J Obes (Lond) 2006; 30: 1091-3.
Moreno LA, Rodriguez G. Dietary risk factors for development of childhood obesity. Curr Opin Clin Nutr Metab Care 2007; 10: 336-41.
Ochoa MC, Moreno-Aliaga MJ, Martinez-Gonzalez MA, Martinez JA, Marti A. Predictor factors for childhood obesity in a Spanish case-control study. Nutrition 2007; 23: 379-84.
Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 2006; 84: 274-88.
Sanchez-Lozada LG, Tapia E, Jimenez A, Bautista P, Cristobal M, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 2007; 292: 423-9.
Ferder L, Ferder MD, Inserra F. The Role of High-Fructose Corn Syrup in Metabolic Syndrome and Hypertension. Curr Hypertens Rep 2010; 12: 105-12.
Tappy L, Le KA. Metabolic Effects of Fructose and the Worldwide Increase in Obesity. Physiol Rev 2010; 90: 23-46.
D'Angelo G, Elmarakby AA, Pollock DM, Stepp DW. Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats. Hypertension 2005; 46: 806-11.
Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987; 10: 512-6.
Tran LT, Yuen VG, McNeill JH. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem 2009; 332: 145-59.
Bhosale SH, Rao MB, Deshpande VV. Molecular and industrial aspects of glucose isomerase. Microbiol Rev 1996; 60: 280-300.
Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr 1993; 58: 754- 65.
Wolf A, Bray GA, Popkin BM. A short history of beverages and how our body treats them. Obes Rev 2008; 9: 151-64.
Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79: 537-43.
Macdonald I, Keyser A, Pacy D. Some effects, in man, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood. Am J Clin Nutr 1978; 31: 1305-11.
Levi B, Werman MJ Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J Nutr 1998; 128: 1442-9.
Havel PJ. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005; 63: 133-57.
Hallfrisch J. Metabolic effects of dietary fructose. FASEB J 1990; 4: 2652-60.
Sánchez-Lozada LG, Tapia E, Soto V, Avila-Casado C, Franco M, Wessale JL, Zhao L, Johnson RJ. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiol 2008; 108: p69-78.
Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006; 290: F625-31.
Stirpe F, Della Corte E, Bonetti E, Abbondanza A, Abbati A, De Stefano F. Fructose-induced hyperuricaemia. Lancet 1970; 2: 1310-1.
Rutledge AC, Adeli K. Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. Nutr Rev 2007; 65: 13-23.
Stanhope KL, Havel PJ. Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 2008; 19: 16-24.
Gao X, Qi L, Qiao N, Choi HK, Curhan G, Tucker KL, Ascherio A. Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension 2007; 50: 306-12.
Taylor EN, Curhan GC. Fructose consumption and the risk of kidney stones. Kidney Int 2008; 73: 207-12.
Asselman M, Verkoelen CF. Fructose intake as a risk factor for kidney stone disease. Kidney Int 2008; 73: 139-40.
Knight J, Assimos DG, Easter L, Holmes RP. Metabolism of fructose to oxalate and glycolate. Horm Metab Res 2010; 42: 868-73.
Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS, Klein S. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003; 348: 2082-90.
Peredo HA, Mayer MA, Rodriguez Fermepin M, Grinspon D, Puyo AM. Oral treatment and in vitro incubation with fructose modify vascular prostanoid production in the rat. Auton Autacoid Pharmacol 2006; 26: 15-20.
Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 2004; 27: 2444-9.
Bayram F, Gündoğan K, Öztürk A, Yazıcı C. Dünya’da ve Türkiye’de metabolik sendromun dağılımı. Turkiye Klinikleri J Int Med Sci 2006; 2: 18-24.
Raben A, Vasilaras TH, Moller AC, Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 2002; 76: 721-9.
Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38: 1101-6.
Alderman MH, Cohen H, Madhavan S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 1999; 34: 144-150.
Vaccarino V, Krumholz HM. Risk factors for cardiovascular disease: one down, many more to evaluate. Ann Intern Med 1999; 131: 62-3.
Nyby MD, Abedi K, Smutko V, Eslami P, Tuck ML. Vascular Angiotensin type 1 receptor expression is associated with vascular dysfunction, oxidative stress and inflammation in fructose-fed rats. Hypertens Res 2007; 30: 451-7.
Busserolles J, Gueux E, Rock E, Demigne C, Mazur A, Rayssiguier Y: Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats. J Nutr 2004; 133: 1903-8.
Shinozaki K, Ayajiki K, Nishio Y, Sugaya T, Kashiwagi A, Okamura T. Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insülin resistance. Hypertension 2004; 43: 255-62.
Bell RC, Carlson JC, Storr KC, Herbert K, Sivak J: Highfructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. Br J Nutr 2000; 84: 575-82.
Miatello R, Risler N, Castro C, Gonzalez S, Ruttler M, Cruzado M: Aortic smooth muscle cell proliferation and endothelial nitric oxide synthase in fructose- fed rats. Am J Hypertens 2001; 14: 1135-141.
Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderon GN, Johnson RJ, Sautin YY: Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol 2009; 20: 545-53.
Kanbay M, Sánchez-Lozada LG, Franco M, Madero M, Solak Y, Rodriguez- Iturbe B, Covic A, Johnson RJ. Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant 2011; 26: 430-7.
Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13: 2888-97.
Wang X, Jia X, Chang T, Desai K, Wu L. Attenuation of Hypertension Development by Scavenging Methylglyoxal in Fructose-Treated Rats. J Hypertens 2008; 26: 765-72.
Yu MA, Sanchez-Lozada LG, Johnson RJ, Kang DH. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens 2010; 28: 1234-42.
Chen L, Caballero B, Mitchell DC, Loria C, Lin PH, Champagne CM, Elmer PJ, Ard JD, Batch BC, Anderson CA, Appel LJ. Reducing consumption of sugar- sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults. Circulation 2010; 121: 2398-406.
Tran LT, Yuen VG, McNeill JH. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem 2009; 332: 145-59.
Jiang J, Tran L, Vasudevan H, Xia Z, Yuen VG, McNeill JH. Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. Can J Physiol Pharmacol 2007; 85: 422-9.
Manitius J, Baines AD, Roszkiewicz A. The effect of high fructose intake on renal morphology and renal function in rats. J Physiol Pharmacol 1995; 46: 179- 83.
Palanisamy N, Viswanathan P, Anuradha CV. Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet. Ren Fail 2008; 30: 645-54.
Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol 2007; 293: F1256-61.