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Tdt positive small round cell tumor: Is this always lymphoblastic leukemia/lymphoma?

Yıl 2013, Cilt: 35 Sayı: 2, 270 - 273, 27.06.2013

Öz

Abstract

Merkel cell carcinoma is a high-grade neuroendocrine carcinoma of the skin characterized by cells with a “blastic” appearance, scanty cytoplasm, evenly distributed chromatin. Terminal deoxy-nucleotidyl transferase is a DNA polymerase expressed by thymic T cells lymphoblastic lymphoma/leukemia and some cases of acute myeloid leukemia. Herein, we report a case of Terminal deoxy-nucleotidyl transferase positive small round cell tumor in consistent with Merkel cell carcinoma.

Keywords: Merkel cell carcinoma, terminal deoxy-nucleotidyl transferase, leukemia, lymphoma

 

Özet

Merkel hücreli karsinom dağılmış kromatine sahip, dar sitoplazmalı, blastic görünümde morfolojiye sahip derinin yüksek gradeli nöroendokrin tümörüdür. Terminal deoksinükleotidil transferaz lenfoblastik lösemi lenfoma ve bazı akut myeloid lösemilerde timik T hücrelerinden eksprese olan bir DNA polimerazdır. Burada terminal deoksinükleotidil transferaz pozitif merkel hücreli karsinom olgusu sunulmaktadır.

Anahtar sözcükler: Merkel hücreli karsinom, terminal deoksinükleotidil transferaz, lösemi, lenfoma

Kaynakça

  • Koljonen V, Böhling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathological study of 34 patients. Eur J Surg Oncol 2003; 29: 607-10.
  • Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation 1999; 68: 1717-21.
  • Pollock J. Merkel cell carcinoma: an uncommon and challenging disease entity. Commun Oncol 2007; 4: 610-2.
  • Meyer Pannwitt U, Kummerfeldt K, Boubaris P, Caselitz J. Merkel cell tumor or neuroendocrine skin carcinoma. Langenbecks Archiv fur Chirurgie 1997; 382: 349Chilosi M, Pizzolo G. Review of terminal deoxynucleotidyl transferase. Biologic aspects, methods of detection, and selected diagnostic applications. Appl Immunohistochem 1995; 3: 209-21.
  • Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 1997; 37: 734Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006; 28: 99-104.
  • Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 1999; 21: 16-20.
  • Mathewson RC, Kjeldsberg CR, Perkins SL. Detection of terminal deoxynucleotidyl transferase (TdT) in nonhematopoietic small round cell tumors of children. Pediatr Pathol Lab Med 1997; 17: 835-44.
  • Bernd HW, Krokowski M, Feller AC, Bartsch S, Thorns C. Expression of terminal desoxynucleotidyl transferase in Merkel cell carcinomas. Histopathology 2007; 50: 676-8.
  • Sur M, AlArdati H, Ross C, Alowami S. TdT expression in Merkel cell carcinoma: Potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20: 1113-20.

Tdt pozitif küçük yuvarlak hücreli tümör: Her zaman lenfoblastik lösemi/lenfoma mıdır?

Yıl 2013, Cilt: 35 Sayı: 2, 270 - 273, 27.06.2013

Öz

Merkel hücreli karsinom dağılmış kromatine sahip, dar sitoplazmalı, blastic görünümde morfolojiye sahip derinin yüksek gradeli nöroendokrin tümörüdür. Terminal deoksinükleotidil transferaz lenfoblastik lösemi lenfoma ve bazı akut myeloid lösemilerde timik T hücrelerinden eksprese olan bir DNA polimerazdır. Burada terminal deoksinükleotidil transferaz pozitif merkel hücreli karsinom olgusu sunulmaktadır.

Kaynakça

  • Koljonen V, Böhling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathological study of 34 patients. Eur J Surg Oncol 2003; 29: 607-10.
  • Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation 1999; 68: 1717-21.
  • Pollock J. Merkel cell carcinoma: an uncommon and challenging disease entity. Commun Oncol 2007; 4: 610-2.
  • Meyer Pannwitt U, Kummerfeldt K, Boubaris P, Caselitz J. Merkel cell tumor or neuroendocrine skin carcinoma. Langenbecks Archiv fur Chirurgie 1997; 382: 349Chilosi M, Pizzolo G. Review of terminal deoxynucleotidyl transferase. Biologic aspects, methods of detection, and selected diagnostic applications. Appl Immunohistochem 1995; 3: 209-21.
  • Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 1997; 37: 734Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006; 28: 99-104.
  • Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 1999; 21: 16-20.
  • Mathewson RC, Kjeldsberg CR, Perkins SL. Detection of terminal deoxynucleotidyl transferase (TdT) in nonhematopoietic small round cell tumors of children. Pediatr Pathol Lab Med 1997; 17: 835-44.
  • Bernd HW, Krokowski M, Feller AC, Bartsch S, Thorns C. Expression of terminal desoxynucleotidyl transferase in Merkel cell carcinomas. Histopathology 2007; 50: 676-8.
  • Sur M, AlArdati H, Ross C, Alowami S. TdT expression in Merkel cell carcinoma: Potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20: 1113-20.
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Olgu Sunumları
Yazarlar

Yasemin Yuyucu Karabulut

Gülşah Kaygusuz

İşınsu Kuzu

Duygu Kankaya

Yayımlanma Tarihi 27 Haziran 2013
Yayımlandığı Sayı Yıl 2013Cilt: 35 Sayı: 2

Kaynak Göster

AMA Yuyucu Karabulut Y, Kaygusuz G, Kuzu İ, Kankaya D. Tdt positive small round cell tumor: Is this always lymphoblastic leukemia/lymphoma?. CMJ. Haziran 2013;35(2):270-273.