Öz
Abstract
Merkel cell carcinoma is a high-grade neuroendocrine carcinoma of the skin characterized by cells with a “blastic” appearance, scanty cytoplasm, evenly distributed chromatin. Terminal deoxy-nucleotidyl transferase is a DNA polymerase expressed by thymic T cells lymphoblastic lymphoma/leukemia and some cases of acute myeloid leukemia. Herein, we report a case of Terminal deoxy-nucleotidyl transferase positive small round cell tumor in consistent with Merkel cell carcinoma.
Keywords: Merkel cell carcinoma, terminal deoxy-nucleotidyl transferase, leukemia, lymphoma
Özet
Merkel hücreli karsinom dağılmış kromatine sahip, dar sitoplazmalı, blastic görünümde morfolojiye sahip derinin yüksek gradeli nöroendokrin tümörüdür. Terminal deoksinükleotidil transferaz lenfoblastik lösemi lenfoma ve bazı akut myeloid lösemilerde timik T hücrelerinden eksprese olan bir DNA polimerazdır. Burada terminal deoksinükleotidil transferaz pozitif merkel hücreli karsinom olgusu sunulmaktadır.
Anahtar sözcükler: Merkel hücreli karsinom, terminal deoksinükleotidil transferaz, lösemi, lenfomaAnahtar Kelimeler
Merkel cell carcinoma terminal deoxy-nucleotidyl transferase leukemia lymphoma
Kaynakça
- Koljonen V, Böhling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathological study of 34 patients. Eur J Surg Oncol 2003; 29: 607-10.
- Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation 1999; 68: 1717-21.
- Pollock J. Merkel cell carcinoma: an uncommon and challenging disease entity. Commun Oncol 2007; 4: 610-2.
- Meyer Pannwitt U, Kummerfeldt K, Boubaris P, Caselitz J. Merkel cell tumor or neuroendocrine skin carcinoma. Langenbecks Archiv fur Chirurgie 1997; 382: 349Chilosi M, Pizzolo G. Review of terminal deoxynucleotidyl transferase. Biologic aspects, methods of detection, and selected diagnostic applications. Appl Immunohistochem 1995; 3: 209-21.
- Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 1997; 37: 734Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006; 28: 99-104.
- Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 1999; 21: 16-20.
- Mathewson RC, Kjeldsberg CR, Perkins SL. Detection of terminal deoxynucleotidyl transferase (TdT) in nonhematopoietic small round cell tumors of children. Pediatr Pathol Lab Med 1997; 17: 835-44.
- Bernd HW, Krokowski M, Feller AC, Bartsch S, Thorns C. Expression of terminal desoxynucleotidyl transferase in Merkel cell carcinomas. Histopathology 2007; 50: 676-8.
- Sur M, AlArdati H, Ross C, Alowami S. TdT expression in Merkel cell carcinoma: Potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20: 1113-20.
Öz
Merkel hücreli karsinom dağılmış kromatine sahip, dar sitoplazmalı, blastic görünümde morfolojiye sahip derinin yüksek gradeli nöroendokrin tümörüdür. Terminal deoksinükleotidil transferaz lenfoblastik lösemi lenfoma ve bazı akut myeloid lösemilerde timik T hücrelerinden eksprese olan bir DNA polimerazdır. Burada terminal deoksinükleotidil transferaz pozitif merkel hücreli karsinom olgusu sunulmaktadır.
Anahtar Kelimeler
Merkel hücreli karsinom terminal deoksinükleotidil transferaz lösemi lenfoma
Kaynakça
- Koljonen V, Böhling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathological study of 34 patients. Eur J Surg Oncol 2003; 29: 607-10.
- Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation 1999; 68: 1717-21.
- Pollock J. Merkel cell carcinoma: an uncommon and challenging disease entity. Commun Oncol 2007; 4: 610-2.
- Meyer Pannwitt U, Kummerfeldt K, Boubaris P, Caselitz J. Merkel cell tumor or neuroendocrine skin carcinoma. Langenbecks Archiv fur Chirurgie 1997; 382: 349Chilosi M, Pizzolo G. Review of terminal deoxynucleotidyl transferase. Biologic aspects, methods of detection, and selected diagnostic applications. Appl Immunohistochem 1995; 3: 209-21.
- Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 1997; 37: 734Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006; 28: 99-104.
- Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 1999; 21: 16-20.
- Mathewson RC, Kjeldsberg CR, Perkins SL. Detection of terminal deoxynucleotidyl transferase (TdT) in nonhematopoietic small round cell tumors of children. Pediatr Pathol Lab Med 1997; 17: 835-44.
- Bernd HW, Krokowski M, Feller AC, Bartsch S, Thorns C. Expression of terminal desoxynucleotidyl transferase in Merkel cell carcinomas. Histopathology 2007; 50: 676-8.
- Sur M, AlArdati H, Ross C, Alowami S. TdT expression in Merkel cell carcinoma: Potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20: 1113-20.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Haziran 2013 |
| Yayımlandığı Sayı | Yıl 2013Cilt: 35 Sayı: 2 |