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Yıl 2019, Cilt: 41 Sayı: 1, 223 - 229, 28.03.2019

Ziya Kalem , Coşkun Şimşir , Turgut Var

https://doi.org/10.7197/223.vi.532805

Öz

Kaynakça

  • 1. Crawford, N. M., & Steiner, A. Z. Age-related infertility. Obstetrics and Gynecology Clinics 2015; 42(1),15-25.
  • 2. Donnez, J., Dolmans, M. M., Pellicer, A., Diaz-Garcia, C., Ernst, E., Macklon, K. T., & Andersen, C. Y. Fertility preservation for age-related fertility decline. The Lancet, 2015; 385(9967), 506-507.
  • 3. Eniola, O. W., Adetola, A. A., & Abayomi, B. T. A review of Female Infertility; important etiological factors and management. Journal of Microbiology and Biotechnology Research 2017; 2(3), 379-385.
  • 4. Tal, R., & Seifer, D. B. Ovarian reserve testing: a user’s guide. American journal of obstetrics and gynecology 2017; 217(2), 129-140.
  • 5. Gleicher N, Weghofer A, Barad D. Too old for IVF: are we discriminating against older women? J Assist Reprod Genet 2007; 24(12), 639-644.
  • 6. Saldeen P, Kallen K, Sundstram P. The probability of successful IVF outcome after poor ovarian response. Acta Obstet Gynecol Scand 2007; 86(4), 457-461.
  • 7. Hsieh Y.Y, Huang C.C, Cheng T.C, Chang C.C, Tsai H.D, Lee M.S. Laser-assisted hatching of embryos is better than the chemical method for enhancing the pregnancy rate in women with advanced age. Fertil Steril 2002;78(1), 179-182.
  • 8. Jirge, P. R. Poor ovarian reserve. Journal of Human Reproductive Sciences 2016;9(2),63.
  • 9. Milki A.A, Hinckley M.D, Behr B. Comparison of blastocyst transfer to day 3 transfer with assisted hatching in the older patient. Fertil Steril 2002;78(6), 1244-1247.
  • 10.Sbracia M, Farina A, Poverini R, Morgia F, Schimberni M, Aragona C.Short versus long gonadotropin-releasing hormone analogue supression protocols for superovulation in patients ≥ 40 years old undergoing intracytoplasmic sperm injection. Fertil Steril 2002; 84(3),644–648.
  • 11. Tsafrir A. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod Biomed Online 2007;14(3),348-355. 12. Pasqualini RS, Quintans CJ. Clinical practice of embryo transfer. Reprod Biomed Online. 2002; 4(1),83-92.
  • 13. Sunderam, S., Kissin, D. M., Crawford, S. B., Folger, S. G., Jamieson, D. J., Warner, L., & Barfield, W. D. Assisted reproductive technology surveillance—United States, 2014. MMWR Surveillance Summaries 2017; 66(6),1.
  • 14. Fernandez-Shaw, S., Cercas, R., Brana, C., Villas, C., & Pons, I. Ongoing and cumulative pregnancy rate after cleavage-stage versus blastocyst-stage embryo transfer using vitrification for cryopreservation: impact of age on the results. Journal of assisted reproduction and genetics 2015; 32(2),177-184.
  • 15. Templeton A, Morris J.K, Parslow W. Factors that effect outcome of IVF treatment. Lancet 1996 ;348(9039),1402-1406. 16. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology, RESOLVE. 1999 Assisted reproductive technology success rates. Atlanta, GA: Centers for Disease Control and Prevention, 2001. 17. Fontaine J.G. Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders. RBM Online 2005;10(1),94-99.
  • 18. Meden-Vrtovec H. Ovarian aging and infertility. Clin Exp Obstet Gynecol 2004; 31: 5-8.
  • 19. Abdalla H, Thum M.Y.An elevated basal FSH reflects a quantitative rather than qualitative decline of the ovarian reserve. Human Reprod 2004; 19(4),893–898.
  • 20. Fong, S. L., Baart, E. B., Martini, E., Schipper, I., Visser, J. A., Themmen, A. P. N., ... & Laven, J. S. E. Anti-Müllerian hormone: a marker for oocyte quantity, oocyte quality and embryo quality?. Reproductive biomedicine online 2008; 16(5),664-670.
  • 21. Swain JE, Pool TB. ART failure:oocyte contributions to unsuccessful fertilization.Hum Reprod Update 2008;14(5),431-446
  • 22. Boucret, L., Chao De La Barca, J. M., Moriniere, C., Desquiret, V., Ferre-L'Hotellier, V., Descamps, P., ... & May-Panloup, P. (2015). Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells. Human reproduction 2015;30(7),1653-1664.
  • 23. Meldrum, D. R., Casper, R. F., Diez-Juan, A., Simon, C., Domar, A. D., & Frydman, R. Aging and the environment affect gamete and embryo potential: can we intervene?. Fertility and sterility 2016;105(3), 548-559.
  • 24.Pellestor F,Andreo B,Arnal F. et al.Maternal aging and chromosomal abnormalities:new data drawn from in vitro unfertilized human oocytes. Human Genetics 2003;112(2),195-203
  • 25.Klipstein S, Regan M, Ryley D.A, Goldman M.B, Alper M.M, Reindollar R.H. One last chance for pregnancy: a review of 2705 invitro fertilization cycles initiated in women age 40 years and above. Fertil Steril 2005;84(2), 433-445.
  • 26. Opsahi MS, Blauer KL, Black SH, Lincoln SR, Thorsell L, Sherins RJ. The number of embryos available for transfer predicts successful pregnancy outcome in women over 39 years with normal ovarian hormonal reserve testing. J Assist Reprod Genet 2001;18(10), 551-556.
  • 27. Veleva Z, Vilska S, Hyden-Granskog C, Tiitinen A, Tapanainen S.J, Martikainen H. Elective single embryo transfer in women aged 36-39 years. Hum Reprod 2006;21(8),2098-2102.
  • 28. Fabregues F, Creus M, Penarrubia J, Manau D, Vanrell J.A, Balasch J. Effects of recombinant human luteinizing hormone supplementation on ovarian stimulation and the implantation rate in down-regulated women of advanced reproductive age. Fertil Steril 2006;85(4), 925–931.
  • 29. Marrs R, Meldrum D, Muasher S, Schoolcraft W, Werlin L, Kelly E.Randomized trial to compare effect of recombinant human FSH(follitrophin alfa) with or without recombinant LH in women undergoing assisted reproduction treatment. Reprod Biomed Online 2004; 8(2), 175–182.
  • 30. Humaidan P, Bungum L, Bungum L, Yding Andersen C. Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH an opening study. Reprod Biomed Online 2004; 8(6), 635-643.
  • 31. Esposito MA, Coutifaris C and Barnhart KT. A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women. Hum Reprod 2002;17(1), 118–123.32. Akande V.A, Keay S.D, Hunt L.P, Mathur R.S, Jenkins J.M, Cahill D.J. The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response. J Assist Reprod Genet 2004; 21(7), 257-262.
  • 32. Akande V.A, Keay S.D, Hunt L.P, Mathur R.S, Jenkins J.M, Cahill D.J. The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response. J Assist Reprod Genet 2004; 21(7), 257-262.
  • 33. Yilmaz, N., Kara, M., Coskun, B., Kaba, M., Erkilinc, S., Yenicesu, O., & Erkaya, S. (2017). Perinatal outcomes and cost-effectivity of the assisted reproduction pregnancies with advanced age: A retrospective analysis. Journal of Obstetrics and Gynaecology, 37(4), 450-453.

The factors that effect in vitro fertilization success in women of critical ages: “38-40 years”

Yıl 2019, Cilt: 41 Sayı: 1, 223 - 229, 28.03.2019

Ziya Kalem , Coşkun Şimşir , Turgut Var

https://doi.org/10.7197/223.vi.532805

Öz

Objective: The aim of this study is to assess the factors that affect IVF success in
women of critical ages of “38-40 years”.

Method: 468 women aged
38-40 years who were admitted for IVF  between January 2013 to
December 2017 were enrolled in the study. Ovarian stimulation characteristics,
number of oocytes retrieved, number of embryos transferred and pregnancy rates
,cancellation rate ,live birth rate were analyzed.

Results: The overall
clinical pregnancy rate was 17.9% . Cancellation rate was 22.4%. The
miscarriage rate was 25% (21/84).The live birth rate was 13.4%
(63/468).Comparing the patients who did and did not achieve conception, we
found statistically meaningful differences in terms of antral follicular count,
retrieved oocyte count, number of embryos obtained, embryo count that was
transferred,. Logistic regression analysis showed that the following factors
were significantly related to higher pregnancy rates: number of embryos
transferred, HMG usage in the stimulation protocol, basal FSH and blastocyst
transfer. 

Conclusions: The most important parameters which predict pregnancy in 38-40 year-old
women are the transfer of a high number of embryos, HMG usage in the
stimulation protocol, low basal FSH level and blastocyst transfer. 









 

Anahtar Kelimeler

Women’s age IVF outcome pregnancy rate

Kaynakça

  • 1. Crawford, N. M., & Steiner, A. Z. Age-related infertility. Obstetrics and Gynecology Clinics 2015; 42(1),15-25.
  • 2. Donnez, J., Dolmans, M. M., Pellicer, A., Diaz-Garcia, C., Ernst, E., Macklon, K. T., & Andersen, C. Y. Fertility preservation for age-related fertility decline. The Lancet, 2015; 385(9967), 506-507.
  • 3. Eniola, O. W., Adetola, A. A., & Abayomi, B. T. A review of Female Infertility; important etiological factors and management. Journal of Microbiology and Biotechnology Research 2017; 2(3), 379-385.
  • 4. Tal, R., & Seifer, D. B. Ovarian reserve testing: a user’s guide. American journal of obstetrics and gynecology 2017; 217(2), 129-140.
  • 5. Gleicher N, Weghofer A, Barad D. Too old for IVF: are we discriminating against older women? J Assist Reprod Genet 2007; 24(12), 639-644.
  • 6. Saldeen P, Kallen K, Sundstram P. The probability of successful IVF outcome after poor ovarian response. Acta Obstet Gynecol Scand 2007; 86(4), 457-461.
  • 7. Hsieh Y.Y, Huang C.C, Cheng T.C, Chang C.C, Tsai H.D, Lee M.S. Laser-assisted hatching of embryos is better than the chemical method for enhancing the pregnancy rate in women with advanced age. Fertil Steril 2002;78(1), 179-182.
  • 8. Jirge, P. R. Poor ovarian reserve. Journal of Human Reproductive Sciences 2016;9(2),63.
  • 9. Milki A.A, Hinckley M.D, Behr B. Comparison of blastocyst transfer to day 3 transfer with assisted hatching in the older patient. Fertil Steril 2002;78(6), 1244-1247.
  • 10.Sbracia M, Farina A, Poverini R, Morgia F, Schimberni M, Aragona C.Short versus long gonadotropin-releasing hormone analogue supression protocols for superovulation in patients ≥ 40 years old undergoing intracytoplasmic sperm injection. Fertil Steril 2002; 84(3),644–648.
  • 11. Tsafrir A. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod Biomed Online 2007;14(3),348-355. 12. Pasqualini RS, Quintans CJ. Clinical practice of embryo transfer. Reprod Biomed Online. 2002; 4(1),83-92.
  • 13. Sunderam, S., Kissin, D. M., Crawford, S. B., Folger, S. G., Jamieson, D. J., Warner, L., & Barfield, W. D. Assisted reproductive technology surveillance—United States, 2014. MMWR Surveillance Summaries 2017; 66(6),1.
  • 14. Fernandez-Shaw, S., Cercas, R., Brana, C., Villas, C., & Pons, I. Ongoing and cumulative pregnancy rate after cleavage-stage versus blastocyst-stage embryo transfer using vitrification for cryopreservation: impact of age on the results. Journal of assisted reproduction and genetics 2015; 32(2),177-184.
  • 15. Templeton A, Morris J.K, Parslow W. Factors that effect outcome of IVF treatment. Lancet 1996 ;348(9039),1402-1406. 16. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology, RESOLVE. 1999 Assisted reproductive technology success rates. Atlanta, GA: Centers for Disease Control and Prevention, 2001. 17. Fontaine J.G. Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders. RBM Online 2005;10(1),94-99.
  • 18. Meden-Vrtovec H. Ovarian aging and infertility. Clin Exp Obstet Gynecol 2004; 31: 5-8.
  • 19. Abdalla H, Thum M.Y.An elevated basal FSH reflects a quantitative rather than qualitative decline of the ovarian reserve. Human Reprod 2004; 19(4),893–898.
  • 20. Fong, S. L., Baart, E. B., Martini, E., Schipper, I., Visser, J. A., Themmen, A. P. N., ... & Laven, J. S. E. Anti-Müllerian hormone: a marker for oocyte quantity, oocyte quality and embryo quality?. Reproductive biomedicine online 2008; 16(5),664-670.
  • 21. Swain JE, Pool TB. ART failure:oocyte contributions to unsuccessful fertilization.Hum Reprod Update 2008;14(5),431-446
  • 22. Boucret, L., Chao De La Barca, J. M., Moriniere, C., Desquiret, V., Ferre-L'Hotellier, V., Descamps, P., ... & May-Panloup, P. (2015). Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells. Human reproduction 2015;30(7),1653-1664.
  • 23. Meldrum, D. R., Casper, R. F., Diez-Juan, A., Simon, C., Domar, A. D., & Frydman, R. Aging and the environment affect gamete and embryo potential: can we intervene?. Fertility and sterility 2016;105(3), 548-559.
  • 24.Pellestor F,Andreo B,Arnal F. et al.Maternal aging and chromosomal abnormalities:new data drawn from in vitro unfertilized human oocytes. Human Genetics 2003;112(2),195-203
  • 25.Klipstein S, Regan M, Ryley D.A, Goldman M.B, Alper M.M, Reindollar R.H. One last chance for pregnancy: a review of 2705 invitro fertilization cycles initiated in women age 40 years and above. Fertil Steril 2005;84(2), 433-445.
  • 26. Opsahi MS, Blauer KL, Black SH, Lincoln SR, Thorsell L, Sherins RJ. The number of embryos available for transfer predicts successful pregnancy outcome in women over 39 years with normal ovarian hormonal reserve testing. J Assist Reprod Genet 2001;18(10), 551-556.
  • 27. Veleva Z, Vilska S, Hyden-Granskog C, Tiitinen A, Tapanainen S.J, Martikainen H. Elective single embryo transfer in women aged 36-39 years. Hum Reprod 2006;21(8),2098-2102.
  • 28. Fabregues F, Creus M, Penarrubia J, Manau D, Vanrell J.A, Balasch J. Effects of recombinant human luteinizing hormone supplementation on ovarian stimulation and the implantation rate in down-regulated women of advanced reproductive age. Fertil Steril 2006;85(4), 925–931.
  • 29. Marrs R, Meldrum D, Muasher S, Schoolcraft W, Werlin L, Kelly E.Randomized trial to compare effect of recombinant human FSH(follitrophin alfa) with or without recombinant LH in women undergoing assisted reproduction treatment. Reprod Biomed Online 2004; 8(2), 175–182.
  • 30. Humaidan P, Bungum L, Bungum L, Yding Andersen C. Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH an opening study. Reprod Biomed Online 2004; 8(6), 635-643.
  • 31. Esposito MA, Coutifaris C and Barnhart KT. A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women. Hum Reprod 2002;17(1), 118–123.32. Akande V.A, Keay S.D, Hunt L.P, Mathur R.S, Jenkins J.M, Cahill D.J. The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response. J Assist Reprod Genet 2004; 21(7), 257-262.
  • 32. Akande V.A, Keay S.D, Hunt L.P, Mathur R.S, Jenkins J.M, Cahill D.J. The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response. J Assist Reprod Genet 2004; 21(7), 257-262.
  • 33. Yilmaz, N., Kara, M., Coskun, B., Kaba, M., Erkilinc, S., Yenicesu, O., & Erkaya, S. (2017). Perinatal outcomes and cost-effectivity of the assisted reproduction pregnancies with advanced age: A retrospective analysis. Journal of Obstetrics and Gynaecology, 37(4), 450-453.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Cerrahi Tıp Bilimleri Araştırma Yazıları
Yazarlar

Ziya Kalem 0000-0002-5435-2074

Coşkun Şimşir 0000-0003-1825-6584

Turgut Var 0000-0002-4479-1399

Yayımlanma Tarihi 28 Mart 2019
Kabul Tarihi 26 Mart 2019
Yayımlandığı Sayı Yıl 2019Cilt: 41 Sayı: 1

Kaynak Göster

AMA Kalem Z, Şimşir C, Var T. The factors that effect in vitro fertilization success in women of critical ages: “38-40 years”. CMJ. Mart 2019;41(1):223-229. doi:10.7197/223.vi.532805