Öz
Özet
Amaç. Bu çalışmada, çocuklarda common melanositik nevus sayısı ile atipik melanositik nevus arasındaki ilişkisinin belirlenmesi amaçlanmaktadır. Yöntem. Cumhuriyet Üniversitesi Tıp Fakültesi Dermatoloji kliniğine ait nevus prevalans ve dermatoskopi kayıtları incelendi ve common ve atipik melanositik nevusu olan tüm çocuklar çalışmaya dahil edildi. Hastaların her biri için common ve atipik melanositik melanositik nevus sayıları kaydedildi. Veriler common ve atipik melanositik nevus arasındaki ilişkiyi belirlemek için istatistiksel olarak analiz edildi. Bulgular. Common ve atipik melanositik nevus sayıları sırasıyla 1168 (74,8%) ve 56 (3,6%) idi. Common melanositik nevusu sayısı daha fazla olanlarda atipik melanositik nevus görülme olasılığının daha yüksek olduğu belirlendi (p = 0,0001). Sonuç. Melanoma gelişimi için önemli bir risk faktörü olan atipik melanositik nevusun mevcudiyeti açısından, çok sayıda common melanositik nevusa sahip çocukların takibi önemlidir.
Anahtar sözcükler: Common melanositik nevus, atipik melanositik nevus, melanom, çocuk, prevalans
Abstract
Aim. In this study, it is aimed to determine the relationship between the number of common melanocytic nevus and the peresence of atypical melanocytic nevus among teenagers. Materials. Nevus prevalence and dermatoscopy records of our dermatology clinic were investigated and all teenager patients (N = 1562) who had common and atypical melanocytic nevus were included. The number of common melanocytic nevus and the presence of atypical melanocytic nevus for each one of all patients were recorded. Data were analysed statistically to determine the relationship between common and atypical melanocytic nevus. Results. The numbers of the patients with common melanocytic nevus and atypical melanocytic nevus were 1168 (74.8%), and 56 (3.6%) respectively. It was noted that the presenting rate of atypical melanocytic nevus increased in those whom had higher common melanocytic nevus numbers (p = 0.0001). Conclusion. In terms of the presence of an atypical melanocytic nevus which is an important risk factor fort the development of melanoma, to follow-up of the children having much more common melanocytic nevus is important.
Keywords: Common melanocytic nevus, atypical melanocytic nevus, melanoma, child, prevalence
Anahtar Kelimeler
Kaynakça
- Öztaş P, İlhan MN, Polat M, Allı N. Clinical and dermoscopic characteristics of melanocytic nevi in Turkish children and their relationship with environmental and constitutional factors. Dermatol Surg 2007; 33: 607-13.
- Grichnk JM, Rhodes AR, Sober AJ. Benign neoplasias and hyperplasias of melanocytes. Wolff K, Goldsmith LA, Katz SI, Gilchrest AB, Paller AS, Leffell DJ ed. Fitzpatrick's Dermatology in General Medicine. 7 th ed. New York: Mc Graw Hill; 2008, p: 1099-122.
- Burden AD, Newell J, Andrew N, Kavanagh G, Connor JM, MacKie RM. Genetic and environmental influences in the development of multiple primary melanoma. Arch Dermatol 1999; 135: 261-5.
- Seykora J, Elder D. Dysplastic nevi and other risk markers for melanoma. Semin Oncol 1996; 23: 682-7.
- Tucker MA. Atypical melanocytic nevi. Wolff K, Goldsmith LA, Katz SI, Gilchrest AB, Paller AS, Leffell DJ ed. Fitzpatrick's Dermatology in General Medicine. 7 th ed. New York: Mc Graw Hill; 2008, p: 1122-33.
- Williams ML, Sagebiel RW. Melanoma risk factors and atypical moles. West J Med 1994; 160: 343-50.
- Freidman T, Wohl Y, Levin A, Levi Y, Brenner S, Dayan YB. Multiple common naevi in Israeli adolescents. Melanoma Research 2006; 16: 89-92.
- Tsao H, Bevona C, Goggins W, Quinn T. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma. Arch Dermatol 2003; 139: 282-8.
- Akyol M, Atlı AG, Özçelik S, Çınar Z, Çiğ, FA, Bircan H: Prevalence of common and atypical melanocytic nevi in Turkish children. Eur J Dermatol 2008; 18: 1-5.
- Valiukeviciene S, Miseviciene I, Gollnick H. The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol 2005; 141: 579-86.
- Kelly JW, River JK, MacLennan R, Harrison S, Lewis AE, Tate BJ. Sunlight: a major factor associated with the development of melanocytic nevi in Australian schoolchildren. J Am Acad Dermatol 1994; 30: 40-8.
- Harrison SL, MacLennan R, Buettner PG. Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiol Biomarkers Prev 2008; 17: 2318-24.
- Carli P, Naldi L, Lovati S, La Vecchia C. The density of melanocytic nevi correlates with constitutional variables and history of sunborns:A prevalence study among Italian schoolchildren. Int J Cancer 2002; 101: 375-9.
- Bataille V, Newton Bishop JA, Sasieni P, Swerdlow AJ, Pinney E, Griffiths K et al. Risk of cutaneous melanoma in relationshipto the number, types and sitesof nevi: a case control study. Br J Cancer 1996; 73: 1605-11.
- Piepkorn M, Meyer LJ, Goldgar D et al. The dysplastic melanocytic nevus- A prevalent lesion that correlates poorly with clinical phenotype. J Am Acad Dermatol 1989; 20: 407- 15.
- Whiteman DC, Brown RM, Purdie DM, Hughes MC. Prevalence and anatomical distribution of naevi in young Queensland children. Int J Cancer 2003; 106: 930-3.
Öz
Amaç. Bu çalışmada, çocuklarda common melanositik nevus sayısı ile atipik melanositik nevus arasındaki ilişkisinin belirlenmesi amaçlanmaktadır. Yöntem. Cumhuriyet Üniversitesi Tıp Fakültesi Dermatoloji kliniğine ait nevus prevalans ve dermatoskopi kayıtları incelendi ve common ve atipik melanositik nevusu olan tüm çocuklar çalışmaya dahil edildi. Hastaların her biri için common ve atipik melanositik melanositik nevus sayıları kaydedildi. Veriler common ve atipik melanositik nevus arasındaki ilişkiyi belirlemek için istatistiksel olarak analiz edildi. Bulgular. Common ve atipik melanositik nevus sayıları sırasıyla 1168 (74,8%) ve 56 (3,6%) idi. Common melanositik nevusu sayısı daha fazla olanlarda atipik melanositik nevus görülme olasılığının daha yüksek olduğu belirlendi (p = 0,0001). Sonuç. Melanoma gelişimi için önemli bir risk faktörü olan atipik melanositik nevusun mevcudiyeti açısından, çok sayıda common melanositik nevusa sahip çocukların takibi önemlidir
Anahtar Kelimeler
Common melanositik nevus atipik melanositik nevus melanom çocuk prevalans
Kaynakça
- Öztaş P, İlhan MN, Polat M, Allı N. Clinical and dermoscopic characteristics of melanocytic nevi in Turkish children and their relationship with environmental and constitutional factors. Dermatol Surg 2007; 33: 607-13.
- Grichnk JM, Rhodes AR, Sober AJ. Benign neoplasias and hyperplasias of melanocytes. Wolff K, Goldsmith LA, Katz SI, Gilchrest AB, Paller AS, Leffell DJ ed. Fitzpatrick's Dermatology in General Medicine. 7 th ed. New York: Mc Graw Hill; 2008, p: 1099-122.
- Burden AD, Newell J, Andrew N, Kavanagh G, Connor JM, MacKie RM. Genetic and environmental influences in the development of multiple primary melanoma. Arch Dermatol 1999; 135: 261-5.
- Seykora J, Elder D. Dysplastic nevi and other risk markers for melanoma. Semin Oncol 1996; 23: 682-7.
- Tucker MA. Atypical melanocytic nevi. Wolff K, Goldsmith LA, Katz SI, Gilchrest AB, Paller AS, Leffell DJ ed. Fitzpatrick's Dermatology in General Medicine. 7 th ed. New York: Mc Graw Hill; 2008, p: 1122-33.
- Williams ML, Sagebiel RW. Melanoma risk factors and atypical moles. West J Med 1994; 160: 343-50.
- Freidman T, Wohl Y, Levin A, Levi Y, Brenner S, Dayan YB. Multiple common naevi in Israeli adolescents. Melanoma Research 2006; 16: 89-92.
- Tsao H, Bevona C, Goggins W, Quinn T. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma. Arch Dermatol 2003; 139: 282-8.
- Akyol M, Atlı AG, Özçelik S, Çınar Z, Çiğ, FA, Bircan H: Prevalence of common and atypical melanocytic nevi in Turkish children. Eur J Dermatol 2008; 18: 1-5.
- Valiukeviciene S, Miseviciene I, Gollnick H. The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol 2005; 141: 579-86.
- Kelly JW, River JK, MacLennan R, Harrison S, Lewis AE, Tate BJ. Sunlight: a major factor associated with the development of melanocytic nevi in Australian schoolchildren. J Am Acad Dermatol 1994; 30: 40-8.
- Harrison SL, MacLennan R, Buettner PG. Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiol Biomarkers Prev 2008; 17: 2318-24.
- Carli P, Naldi L, Lovati S, La Vecchia C. The density of melanocytic nevi correlates with constitutional variables and history of sunborns:A prevalence study among Italian schoolchildren. Int J Cancer 2002; 101: 375-9.
- Bataille V, Newton Bishop JA, Sasieni P, Swerdlow AJ, Pinney E, Griffiths K et al. Risk of cutaneous melanoma in relationshipto the number, types and sitesof nevi: a case control study. Br J Cancer 1996; 73: 1605-11.
- Piepkorn M, Meyer LJ, Goldgar D et al. The dysplastic melanocytic nevus- A prevalent lesion that correlates poorly with clinical phenotype. J Am Acad Dermatol 1989; 20: 407- 15.
- Whiteman DC, Brown RM, Purdie DM, Hughes MC. Prevalence and anatomical distribution of naevi in young Queensland children. Int J Cancer 2003; 106: 930-3.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 6 Temmuz 2009 |
| Yayımlandığı Sayı | Yıl 2009Cilt: 31 Sayı: 3 |