Öz
Abstract
Aim. This report retrospectively documents the management of in 11 patients with thymoma at Ankara Numune Education and Research Hospital Radiation Oncology Department from 1999 to 2007. Method. A total of eleven patients that admitted with the diagnosis of thymoma to own clinic between November 1999 and April 2007 were included. The medical files of the patients were retrospectively reviewed. Gender, age, subtype of thymoma, surgical procedures performed and radiotherapy doses were taken into consideration. Result. There were one patient with Type B1 thymoma, one with type B3 thymoma and nine patients with type B2. Eight patients underwent surgery, while three had biopsy alone. Overall survival rate was 71% and mean survival duration was 56 months. There was no statistically significant differences in survival rate with respect to sex, mean survival rate was 73% in males and 60% in females. Although the survival rate was higher in patients that underwent surgery than those that underwent biopsy alone, the difference was not statistically significant (75% vs 66%, respectively). Conclusion. Survival rate was increased in patients with thymoma by radiotherapy and our results are similar with literatures.
Key words: Thymoma, timus, tumor, resection
Özet
Amaç. Ankara Numune Eğitim ve Araştırma Hastanesi Radyasyon Onkolojisi Kliniği’nde 1999-2007 yılları arasında tedavi gören 11 timoma olgusu retrospektif olarak değerlendirildi. Yöntem. Kasım 1999 ile Nisan 2007 tarihleri arasında kliniğimize timoma tanısı ile başvuran 11 hasta çalışmaya dahil edildi. Hastaların dosyaları retrospektif olarak incelendi. Cinsiyet, yaş, timoma alt tipi, cerrahi tipi ve tedavi dozunda değerlendirmeye alındı. Bulgular. Hastalardan 1’i tip B1 timoma, 1’i tip B3 timoma, geri kalan 9 hasta ise Tip B2 timomadır. Hastalardan 8’ine cerrahi tedavi, 3’üne sadece biyopsi uygulanmıştır. Genel sağkalım %71 olarak bulundu. Ortalama sağkalım 56 aydır. Cinsiyete göre istatistiksel olarak anlam saptanmadı; erkek cinsiyette sağkalım %73, kadın cinsiyette %60’dır. Operasyon açısından sağkalım; biopsi uygulananlarda %66, opere olanlarda %75 olarak bulundu. Sonuç. Timoma tanılı hastalarda sağkalım radyoterapi ile yükselmiştir ve bulgularımız literatür ile uyumludur.
Anahtar sözcükler: Timoma, timus, tümör, rezeksiyon
Anahtar Kelimeler
Kaynakça
- Hardy JD, Eving HP. The Mediastinum. In: Glenn W, ed. Thoracic and Cardiovascular Surg, 1983:407-37.
- Davis RD, Oldham HN, Sablston DC. The Mediastinum. In: Sablston DC, Spencer FC, eds. Surgery of the Chest. WB Saunders Comp, 1990:495-535.
- Hartmann CA, Roth C, Minck C, Niedobitek G. Thymic carcinoma; Report of five cases and review of literature. J Cancer Res Clin Oncol 1990; 116: 69-82.
- Rosai J. Ackerman's Surgical Pathology. CV Mosby Comp 1989:350-6.
- Whittaker LD and Lynn HB. Mediastinal tumors and cysts in the pediatric patient (symposium on surgery of the chest). Surg Clin North Am 1973; 53: 893-904.
- Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, Taylor WF. A clinicopathologic review. Cancer 1987; 60: 2727-43.
- Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981; 48:2485-92.
- Monden Y, Nakahara K, Iioka S, Nanjo S, Ohno K, Fujii Y, Hashimoto J, Kitagawa Y, Masaoka A, Kawashima Y. Recurrence of thymoma: Clinicopathological features, therapy and prognosis. Ann Thorac Surg 1985; 39: 165-9.
- Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E. Results of 241 operated cases. Ann Thorac Surg 1991; 51:152-6.
- Braitman H, Herrmann C, Mulder DG. Surgery for thymic tumors. Arch Surg 1971; 103:14-6.
- Cohen DJ, Ronnigen LD, Graeber GM, Deshong JL, Jaffin J, Burge JR, Zajtchuk R. Management of patients with malignant thymoma. J Thorac Cardiovasc Surg 1984; 87: 301-7.
- Nakahara K, Ohno K, Hashimoto J, Maeda H, Miyoshi S, Sakurai M, Monden. Y, Kamashima Y. Thymoma: result with complete resection and adjuvant postoperative irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg 1988; 95:1041-7.
- Blumberg D, Port JL, Weksler B, Delgado R, Rosai J, Bains MS, Ginsberg RJ. Thymoma: multivariate analysis of factors predicting survival. Ann Thorac Surg 1995; 60:908-14.
- Pescarmona E, Rendina EA, Venuta F, D'Arcangelo E, Pagani M, Ricci C, Ruco LP, Baroni CD. Analysis of prognostic factors and clinicopathological staging of thymoma. Ann Thorac Surg 1990; 50:534-8.
- Chen YD, Feng QF, Lu HZ, Mao YS, Zhou ZM, Ou GF, Wang M, Zhao J, Zhang HX, Xiao ZF, Chen DF, Liang J, Zhai YR, Wang LH, He J. Role of Adjuvant Radiotherapy for Stage II Thymoma after Complete Tumor Resection. Int J Radiat Oncol Biol Phys. 2010 Apr 6. [Epub ahead of print]
- Regnard JF, Magdeleinat P, Dromer C, Dulmet E, de Montpreville V, Levi JF, Levasseur P. Prognostic factors and long-term results after thymoma resection: A series of 307 patients. J Thorac Cardiovasc Surg. 1996; 112: 376-83.
- Fuentes P, Leude E, Ruiz C, Bordigoni L, Thomas P, Giudicelli R, Gastaud JA, Morati N. Treatment of thymoma:A report of 67 cases. Eur J Cardioc Thorac Surg 1992; 6: 180-8.
- Stremmel C, Dango S, Thiemann U, Kayser G, Passlick B. Thymoma--incidence, classification and therapy. Dtsch Med Wochenschr. 2007; 132:2090-5.
- Girard N, Mornex F, Van Houtte P, Cordier JF, Van Schil P.Thymoma: a focus on current therapeutic management. J Thorac Oncol. 2009; 4:119-26.
- Myojin M, Choi NC, Wright CD, Wain JC, Harris N, Hug EB, Mathisen DJ, Lynch T, Carey RW, Grossbard M, Finkelstein DM, Grillo HC. Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. Int J Radiat Oncol Biol Phys. 2000; 46: 927-33.
Öz
Ankara Numune Eğitim ve Araştırma Hastanesi Radyasyon Onkolojisi Kliniği’nde 1999-2007 yılları arasında tedavi gören 11 timoma olgusu retrospektif olarak değerlendirildi. Hastalardan 1’i tip B1 timoma, 1’i tip B3 timoma, geri kalan 9 hasta ise Tip B2 timomadır. Hastalardan 8’ine cerrahi tedavi, 3’üne sadece biopsi uygulanmıştır. Genel sağkalım %71 olarak bulunmuştur. Ortalama sağkalım 56 aydır. Cinsiyete göre istatistiksel olarak anlam saptanmamıştır; erkek cinsiyette sağkalım %73, kadın cinsiyette %60’dır. Operasyon açısından sağkalım; biopsi uygulananlarda %66, opere olanlarda %75 olarak bulunmuştur.
Anahtar kelimeler: Timoma, timus, tümör, rezeksiyon
Anahtar Kelimeler
Kaynakça
- Hardy JD, Eving HP. The Mediastinum. In: Glenn W, ed. Thoracic and Cardiovascular Surg, 1983:407-37.
- Davis RD, Oldham HN, Sablston DC. The Mediastinum. In: Sablston DC, Spencer FC, eds. Surgery of the Chest. WB Saunders Comp, 1990:495-535.
- Hartmann CA, Roth C, Minck C, Niedobitek G. Thymic carcinoma; Report of five cases and review of literature. J Cancer Res Clin Oncol 1990; 116: 69-82.
- Rosai J. Ackerman's Surgical Pathology. CV Mosby Comp 1989:350-6.
- Whittaker LD and Lynn HB. Mediastinal tumors and cysts in the pediatric patient (symposium on surgery of the chest). Surg Clin North Am 1973; 53: 893-904.
- Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, Taylor WF. A clinicopathologic review. Cancer 1987; 60: 2727-43.
- Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981; 48:2485-92.
- Monden Y, Nakahara K, Iioka S, Nanjo S, Ohno K, Fujii Y, Hashimoto J, Kitagawa Y, Masaoka A, Kawashima Y. Recurrence of thymoma: Clinicopathological features, therapy and prognosis. Ann Thorac Surg 1985; 39: 165-9.
- Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E. Results of 241 operated cases. Ann Thorac Surg 1991; 51:152-6.
- Braitman H, Herrmann C, Mulder DG. Surgery for thymic tumors. Arch Surg 1971; 103:14-6.
- Cohen DJ, Ronnigen LD, Graeber GM, Deshong JL, Jaffin J, Burge JR, Zajtchuk R. Management of patients with malignant thymoma. J Thorac Cardiovasc Surg 1984; 87: 301-7.
- Nakahara K, Ohno K, Hashimoto J, Maeda H, Miyoshi S, Sakurai M, Monden. Y, Kamashima Y. Thymoma: result with complete resection and adjuvant postoperative irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg 1988; 95:1041-7.
- Blumberg D, Port JL, Weksler B, Delgado R, Rosai J, Bains MS, Ginsberg RJ. Thymoma: multivariate analysis of factors predicting survival. Ann Thorac Surg 1995; 60:908-14.
- Pescarmona E, Rendina EA, Venuta F, D'Arcangelo E, Pagani M, Ricci C, Ruco LP, Baroni CD. Analysis of prognostic factors and clinicopathological staging of thymoma. Ann Thorac Surg 1990; 50:534-8.
- Chen YD, Feng QF, Lu HZ, Mao YS, Zhou ZM, Ou GF, Wang M, Zhao J, Zhang HX, Xiao ZF, Chen DF, Liang J, Zhai YR, Wang LH, He J. Role of Adjuvant Radiotherapy for Stage II Thymoma after Complete Tumor Resection. Int J Radiat Oncol Biol Phys. 2010 Apr 6. [Epub ahead of print]
- Regnard JF, Magdeleinat P, Dromer C, Dulmet E, de Montpreville V, Levi JF, Levasseur P. Prognostic factors and long-term results after thymoma resection: A series of 307 patients. J Thorac Cardiovasc Surg. 1996; 112: 376-83.
- Fuentes P, Leude E, Ruiz C, Bordigoni L, Thomas P, Giudicelli R, Gastaud JA, Morati N. Treatment of thymoma:A report of 67 cases. Eur J Cardioc Thorac Surg 1992; 6: 180-8.
- Stremmel C, Dango S, Thiemann U, Kayser G, Passlick B. Thymoma--incidence, classification and therapy. Dtsch Med Wochenschr. 2007; 132:2090-5.
- Girard N, Mornex F, Van Houtte P, Cordier JF, Van Schil P.Thymoma: a focus on current therapeutic management. J Thorac Oncol. 2009; 4:119-26.
- Myojin M, Choi NC, Wright CD, Wain JC, Harris N, Hug EB, Mathisen DJ, Lynch T, Carey RW, Grossbard M, Finkelstein DM, Grillo HC. Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. Int J Radiat Oncol Biol Phys. 2000; 46: 927-33.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 2 Haziran 2010 |
| Yayımlandığı Sayı | Yıl 2010Cilt: 32 Sayı: 3 |